Mirteimouri Masoumeh, Pourali Leila, Soltani Mozhgan, Salehi Maryam, Vatanchi Atiyeh, Abolkheir Akram Zarei
Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Socio-medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Oman Med J. 2021 Mar 31;36(2):e250. doi: 10.5001/omj.2021.58. eCollection 2021 Mar.
Recently, intravenous acetaminophen has been introduced as an intervention with analgesic potential similar to that of opioid analgesics in labor pain management. This study aimed to compare the pain score and maternal and neonatal complications following acetaminophen and pethidine injections during vaginal delivery.
This randomized, double-blind clinical trial was conducted on pregnant women during the first stage of delivery referred to Ghaem and Omolbanin Hospitals in Mashhad, Iran, from March to December 2017. The subjects were assigned randomly to one of two groups: acetaminophen and pethidine. The pain intensity was measured before and 15, 60, 120, 180, and 240 minutes after injection.
The pain score and pain score changes showed no significant difference between the two groups at different times. The incidence of maternal complications during delivery and the first hour after delivery was not statistically significant between the two groups, but 15 minutes after injection, vomiting ( 0.001), nausea ( 0.001), and dizziness ( 0.001) were significantly higher in the pethidine group. The mean one and five minutes Apgar scores were significantly higher in the acetaminophen group.
Intravenous acetaminophen led to fewer maternal complications than pethidine, especially during the first 15 minutes after injection and fewer neonatal complications, especially in the Apgar score.
最近，静脉注射对乙酰氨基酚已被引入作为一种干预措施，其在分娩疼痛管理中的镇痛潜力与阿片类镇痛药相似。本研究旨在比较阴道分娩期间注射对乙酰氨基酚和哌替啶后的疼痛评分以及母婴并发症。
本随机、双盲临床试验于2017年3月至12月在伊朗马什哈德的加姆医院和奥莫尔巴宁医院对分娩第一阶段的孕妇进行。受试者被随机分配到两组之一：对乙酰氨基酚组和哌替啶组。在注射前以及注射后15、60、120、180和240分钟测量疼痛强度。
两组在不同时间的疼痛评分及疼痛评分变化无显著差异。两组在分娩期间及分娩后第一小时的产妇并发症发生率无统计学意义，但注射后15分钟，哌替啶组的呕吐（0.001）、恶心（0.001）和头晕（0.001）发生率显著更高。对乙酰氨基酚组的1分钟和5分钟阿氏评分均值显著更高。
静脉注射对乙酰氨基酚导致的产妇并发症比哌替啶少，尤其是在注射后的前15分钟，且新生儿并发症少，尤其是在阿氏评分方面。
