Ali-Khiavi Payam, Mohammadi Mahya, Masoumi Sajjad, Saffarfar Hossein, Kheradmand Reza, Mobed Ahmad, Hatefnia Faezeh
Medical faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cell Biochem Biophys. 2025 Mar;83(1):307-326. doi: 10.1007/s12013-024-01564-7. Epub 2024 Oct 3.
Infection occurs when pathogens penetrate tissues, reproduce, and trigger a host response to both the infectious agents and their toxins. A diverse array of pathogens, including viruses and bacteria, can cause infections. The host's immune system employs several mechanisms to combat these infections, typically involving an innate inflammatory response. Inflammation is a complex biological reaction that can affect various parts of the body and is a key component of the response to harmful stimuli. Sepsis arises when the body's response to infection leads to widespread damage to tissues and organs, potentially resulting in severe outcomes or death. The initial phase of sepsis involves immune system suppression. Early identification and targeted management are crucial for improving sepsis outcomes. Common treatment approaches include antibiotics, intravenous fluids, blood cultures, and monitoring urine output. This study explores the potential of exosome therapy in enhancing the management and alleviation of sepsis symptoms.
当病原体侵入组织、繁殖并引发宿主对感染因子及其毒素的反应时,感染就会发生。包括病毒和细菌在内的各种各样的病原体都可能导致感染。宿主的免疫系统采用多种机制来对抗这些感染,通常涉及先天性炎症反应。炎症是一种复杂的生物反应,可影响身体的各个部位,是对有害刺激作出反应的关键组成部分。当身体对感染的反应导致组织和器官广泛受损时,就会发生脓毒症,可能导致严重后果甚至死亡。脓毒症的初始阶段涉及免疫系统抑制。早期识别和针对性治疗对于改善脓毒症的治疗效果至关重要。常见的治疗方法包括使用抗生素、静脉输液、血培养和监测尿量。本研究探讨了外泌体疗法在加强脓毒症管理和缓解脓毒症症状方面的潜力。