Chen Yi-Ming, Wang I-Lin, Zhu Xin-Yi, Chiu Wan-Chun, Chiu Yen-Shuo
The College of Physical Education, Hubei Normal University, Huangshi, China.
Graduate Institute, Jilin Sport University, Changchun, China.
Front Nutr. 2021 Apr 14;8:623698. doi: 10.3389/fnut.2021.623698. eCollection 2021.
In red clover ( L.; RC) the main compound is isoflavones, which are selective estrogen receptor modulators for maintaining female health. Isoflavones exert antifatigue effects during exercise in high-temperature environments. This study aimed to investigate the effect of RC supplementation on gut microbiota composition to determine whether it improves intestinal barrier function and exercise performance. Female ICR mice were divided into four groups ( = 8 per group) and orally administered RC once daily for 6 weeks at 0 (vehicle), 308 (RC-1X), 615 (RC-2X), and 1,538 (RC-5X) mg/kg. RC supplementation decreased the fat mass and increased exhaustive swimming time, grip strength, and muscle glycogen in female mice. In the RC supplementation group, serum levels of lactate, ammonia, and creatine kinase decreased after swimming. The estradiol and progesterone levels were higher in the RC group than in the vehicle group. Regarding gut microbiota composition, the RC-2X group may increase intestinal health related to the microorganisms and . Thus, the use of RC supplements as nutraceuticals could have positive effects on athletes' gut and overall health.
在红三叶草（L.；RC）中，主要化合物是异黄酮，它们是用于维持女性健康的选择性雌激素受体调节剂。异黄酮在高温环境下运动期间发挥抗疲劳作用。本研究旨在调查补充RC对肠道微生物群组成的影响，以确定其是否能改善肠道屏障功能和运动表现。将雌性ICR小鼠分为四组（每组n = 8），并分别以0（载体）、308（RC-1X）、615（RC-2X）和1538（RC-5X）mg/kg的剂量每日口服RC一次，持续6周。补充RC可降低雌性小鼠的脂肪量，并增加其力竭游泳时间、握力和肌肉糖原。在补充RC组中，游泳后血清乳酸、氨和肌酸激酶水平降低。RC组的雌二醇和孕酮水平高于载体组。关于肠道微生物群组成，RC-2X组可能会增加与微生物 和 相关的肠道健康。因此，将RC补充剂用作营养保健品可能对运动员的肠道和整体健康产生积极影响。
