Nursing Care Research Center, Department of Nursing Management, School of Nursing & Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Nursing Care Research Center, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Biomed Res Int. 2021 Apr 9;2021:6630404. doi: 10.1155/2021/6630404. eCollection 2021.
To describe and synthesize aspects of knowledge, attitudes, and practice regarding pharmacovigilance and adverse drug reaction (ADR) reporting and to explore associated barriers from a nurse perspective.
A systematic review was conducted. Electronic databases including MEDLINE, Embase, Scopus, and Web of Knowledge from January 2010 to October 2020 were searched. Original observational studies that were written in English and which focused on nurses' knowledge, attitudes, practice, and perceived barriers regarding pharmacovigilance and ADR reporting in various healthcare settings were included.
Twenty-three studies published in English from 2010 to 2020 were retrieved during the search process. Overall, in the knowledge domain, the median percentages of nurses who were aware of the definitions of ADRs were 74.1%, while only 26.3% were aware of the adverse drug reaction reporting form. In the attitude domain, 84.6% of nurses believed ADR reporting to be important for patient/medicine safety and 37.1% had a fear of legal liability following ADR reporting. Although 67.1% of nurses encountered ADRs during their professional life, only 21.2% had a history of ADR reporting. In addition, lack of knowledge/training (median: 47.1%) was identified as the most common barrier in ADR reporting from a nursing viewpoint.
Despite positive nurse attitudes, knowledge and practice in relation to pharmacovigilance activities and ADR reporting did not occur regularly or often. Improving nurses' knowledge through in-service training and degree-level education and addressing the main barriers of ADR reporting may help to achieve an improved level of reporting.
描述和综合药学监测和药物不良反应（ADR）报告方面的知识、态度和实践，并从护士角度探讨相关障碍。
进行了系统综述。从 2010 年 1 月至 2020 年 10 月，检索了 MEDLINE、Embase、Scopus 和 Web of Knowledge 等电子数据库。纳入的原始观察性研究以英语撰写，重点关注护士在各种医疗保健环境中对药物监测和 ADR 报告的知识、态度、实践和感知障碍。
在搜索过程中检索到 2010 年至 2020 年期间发表的 23 篇英文研究。总体而言，在知识领域，知晓 ADR 定义的护士中位数百分比为 74.1%，而只有 26.3%知晓 ADR 报告表。在态度领域，84.6%的护士认为 ADR 报告对患者/药物安全很重要，37.1%的护士在报告 ADR 后担心法律责任。尽管 67.1%的护士在职业生涯中遇到过 ADR，但只有 21.2%有过 ADR 报告史。此外，从护理角度来看，缺乏知识/培训（中位数：47.1%）被认为是 ADR 报告的最常见障碍。
尽管护士态度积极，但药物监测活动和 ADR 报告方面的知识和实践并没有经常或定期发生。通过在职培训和学位教育提高护士的知识水平，并解决 ADR 报告的主要障碍，可能有助于提高报告水平。
