J Drugs Dermatol. 2021 May 1;20(5):519-522. doi: 10.36849/JDD.5751.
Dinoprostone (DNP), a prostaglandin E2 (PGE2) analogue, has been found to cause repigmenation in vitiliginous lesions. Combined medical and surgical therapy might be more useful for successful treatment of vitiligo.
In this study, we aimed to evaluate the efficacy and safety of dermabrasion followed by dinoprostone gel and to compare it with tacrolimus ointment following the same procedure in the treatment of localized stable vitiligo.
40 patients of stable vitiligo were enrolled which were divided in two groups of 20 patients each. In group 1, dermabrasion followed by tacrolimus 0.1% ointment was done and in group 2, dermabrasion followed by dinoprostone gel was done.
Group 1 patients showed slightly better response (P=0.039), whereas the side effect profile was better for group 2.
DNP and tacrolimus have immunomodulatory and melanocyte stimulating effect and are well tolerated when combined with dermabrasion. Their effect on skin pigmentation could be enhanced by dermabrasion. J Drugs Dermatol. 2021;20(5):519-522. doi:10.36849/JDD.5751.
地诺前列酮（DNP）是一种前列腺素 E2（PGE2）类似物，已被发现可引起白癜风病变的复色。联合医学和手术治疗可能更有助于成功治疗白癜风。
本研究旨在评估磨皮术联合地诺前列酮凝胶治疗局限性稳定型白癜风的疗效和安全性，并与磨皮术联合他克莫司软膏进行比较。
将 40 例稳定型白癜风患者分为两组，每组 20 例。在第 1 组中，进行磨皮术联合他克莫司 0.1%软膏治疗，在第 2 组中，进行磨皮术联合地诺前列酮凝胶治疗。
第 1 组患者的反应略好（P=0.039），而第 2 组的副作用较轻。
DNP 和他克莫司具有免疫调节和黑素细胞刺激作用，与磨皮术联合使用时耐受性良好。磨皮术可增强它们对皮肤色素沉着的作用。J 皮肤病学杂志。2021；20(5):519-522.doi:10.36849/JDD.5751.
