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用于人类病毒检测的电化学发光生物传感器的最新趋势与进展

Recent trends and advancements in electrochemiluminescence biosensors for human virus detection.

作者信息

Sobhanie Ebtesam, Salehnia Foad, Xu Guobao, Hamidipanah Yalda, Arshian Shayesteh, Firoozbakhtian Ali, Hosseini Morteza, Ganjali Mohammad Reza, Hanif Saima

机构信息

Nanobiosensors Lab, Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran.

Departament d'Enginyeria Electrònica, Escola Tècnica Superior d'Enginyeria, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.

出版信息

Trends Analyt Chem. 2022 Dec;157:116727. doi: 10.1016/j.trac.2022.116727. Epub 2022 Jul 5.

Abstract

Researchers are constantly looking to find new techniques of virus detection that are sensitive, cost-effective, and accurate. Additionally, they can be used as a point-of-care (POC) tool due to the fact that the populace is growing at a quick tempo, and epidemics are materializing greater often than ever. Electrochemiluminescence-based (ECL) biosensors for the detection of viruses have become one of the most quickly developing sensors in this field. Thus, we here focus on recent trends and developments of these sensors with regard to virus detection. Also, quantitative analysis of various viruses (e.g., Influenza virus, SARS-CoV-2, HIV, HPV, Hepatitis virus, and Zika virus) with a specific interest in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was introduced from the perspective of the biomarker and the biological receptor immobilized on the ECL-based sensors, such as nucleic acids-based, immunosensors, and other affinity ECL biosensors.

摘要

研究人员一直在寻找灵敏、经济高效且准确的病毒检测新技术。此外,鉴于人口增长迅速且流行病比以往任何时候都更频繁地出现,这些技术可作为即时检测(POC)工具使用。用于病毒检测的基于电化学发光(ECL)的生物传感器已成为该领域发展最快的传感器之一。因此,我们在此关注这些传感器在病毒检测方面的最新趋势和发展。此外,还从固定在基于ECL的传感器上的生物标志物和生物受体(如基于核酸的传感器、免疫传感器和其他亲和ECL生物传感器)的角度,介绍了对各种病毒(如流感病毒、SARS-CoV-2、HIV、HPV、肝炎病毒和寨卡病毒)的定量分析,特别关注严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae1b/9254503/0b1e5d6f0adf/sc1_lrg.jpg

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