Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Center for Disabilities and Development, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.
Nutr Neurosci. 2022 Jul;25(7):1558-1564. doi: 10.1080/1028415X.2021.1879541. Epub 2021 May 3.
Oxidative stress has been implicated in the pathogenesis of neurodevelopmental disorders. As an anti-oxidative agent, selenium plays an important role in human health. However, the relationship between selenium status and learning disability (LD), a common neurodevelopmental disorder, is unknown.
To examine the association between serum selenium concentrations and learning disability.
Nationwide, population-based, cross-sectional study.
PARTICIPANTS/SETTING: Children aged 4-11 years who have available data on serum selenium concentrations and LD ( = 1,076) from the U.S. National Health and Nutrition Examination Survey 1999-2000.
Serum selenium levels were measured using atomic absorption spectrometry.
Diagnosis of LD was reported by the children's parents.
Logistic regression models with survey weights were conducted adjusting for age, race/ethnicity, family income, total energy intake, body mass index, and serum cotinine levels.
In this study, 8.2% (95% confidence interval [CI] 5.2%-11.2%) of children had a diagnosis of LD. Serum selenium concentration was lower among children with LD than those without LD (geometric mean ± standard error, 107.7 ± 2.7 ng/mL vs. 112.8 ± 1.0 ng/mL, P for difference = 0.08). The adjusted odds ratio (OR) of LD comparing the highest with lowest tertile of serum selenium concentrations was 0.39 (95% CI 0.19-0.82). Each 10 ng/mL increment in serum selenium concentrations was associated with 31% (OR 0.69, 95% CI 0.51-0.93) lower odds of LD.
Higher serum selenium concentration was associated with a lower risk of LD in U.S. children. The causal relationship between selenium and LD and the underlying mechanisms warrant further investigation.
氧化应激与神经发育障碍的发病机制有关。作为一种抗氧化剂，硒在人类健康中起着重要作用。然而，硒的状态与学习障碍（LD）之间的关系尚不清楚，LD 是一种常见的神经发育障碍。
研究血清硒浓度与学习障碍之间的关系。
全国范围内、基于人群的横断面研究。
参与者/设置：美国国家健康和营养调查 1999-2000 年的数据中，年龄在 4-11 岁之间，血清硒浓度和 LD 数据（ = 1076）可用的儿童。
采用原子吸收光谱法测量血清硒水平。
LD 的诊断由儿童家长报告。
采用带有调查权重的逻辑回归模型进行分析，调整了年龄、种族/民族、家庭收入、总能量摄入、体重指数和血清可替宁水平。
在这项研究中，8.2%（95%置信区间[CI]为 5.2%-11.2%）的儿童被诊断为 LD。与无 LD 的儿童相比，有 LD 的儿童血清硒浓度较低（几何均数 ± 标准误差，107.7 ± 2.7 ng/mL 比 112.8 ± 1.0 ng/mL，P 差值=0.08）。比较血清硒浓度最高和最低三分位的 LD 的调整比值比（OR）为 0.39（95%CI 0.19-0.82）。血清硒浓度每增加 10 ng/mL，LD 的可能性降低 31%（OR 0.69，95%CI 0.51-0.93）。
美国儿童血清硒浓度较高与 LD 风险降低相关。硒与 LD 之间的因果关系及其潜在机制需要进一步研究。
