The National Clinical Research Center for Mental Disorder and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Front Public Health. 2022 Sep 30;10:972368. doi: 10.3389/fpubh.2022.972368. eCollection 2022.
The association between acrylamide exposure and the odds of developmental disabilities (DDs) is unclear. We conducted this analysis to explore whether acrylamide exposure is related to DDs.
We analyzed a sample of 1,140 children aged 6-17 years old from the US National Health and Nutrition Examination Survey 2013-2014 to 2015-2016. DDs were determined by reports of parents. Acrylamide exposure was evaluated by the hemoglobin adducts of acrylamide (HbAA) and its major metabolite glycidamide (HbGA). We investigated the association using binomial logistic regression analysis by taking HbAA and HbGA as continuous or quartile variables. Restricted cubic splines (RCS) were used to explore the non-linear relationship between HbAA or HbGA and the odds of DDs. Interaction analysis and propensity score matching (PSM) were used to validate the results.
A total of 134 participants were reported to have DDs. The median level of HbAA and HbGA was 41.6 and 40.5 pmol/g Hb, respectively. HbAA and HbGA were not associated with the odds of DDs when taken as continuous variables. When divided into quartiles, there was no evidence for a linear trend for HbAA and HbGA. RCS showed that there was a J-shaped association between HbGA and the odds of DDs ( for non-linearity, 0.023). The results were consistent in interaction analysis by age, gender, and race, and after PSM.
HbGA level was associated with the odds of DDs in a J-shaped manner among children. Further investigation is warranted to determine the causality and underlying mechanisms.
丙烯酰胺暴露与发育障碍（DDs）的几率之间的关系尚不清楚。我们进行了这项分析，以探讨丙烯酰胺暴露是否与 DDs 有关。
我们分析了来自美国国家健康和营养检查调查 2013-2014 年至 2015-2016 年的 1140 名 6-17 岁儿童的样本。DDs 由父母报告确定。丙烯酰胺暴露通过丙烯酰胺（HbAA）和其主要代谢物缩水甘油酰胺（HbGA）的血红蛋白加合物来评估。我们通过将 HbAA 和 HbGA 作为连续或四分位数变量来使用二项逻辑回归分析来研究关联。限制性立方样条（RCS）用于探索 HbAA 或 HbGA 与 DDs 几率之间的非线性关系。交互分析和倾向评分匹配（PSM）用于验证结果。
共有 134 名参与者报告患有 DDs。HbAA 和 HbGA 的中位数水平分别为 41.6 和 40.5 pmol/g Hb。当作为连续变量时，HbAA 和 HbGA 与 DDs 的几率无关。当分为四分位数时，HbAA 和 HbGA 没有线性趋势的证据。RCS 显示 HbGA 与 DDs 的几率之间存在 J 形关联（非线性，0.023）。在按年龄、性别和种族进行的交互分析以及 PSM 后，结果一致。
HbGA 水平与儿童 DDs 的几率呈 J 形相关。需要进一步调查以确定因果关系和潜在机制。
