Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Mohammed V University in Rabat, LPCMIO, Materials Science Center (MSC), Ecole Normale Supérieure, Rabat, Morocco.
J Ethnopharmacol. 2021 Aug 10;276:114171. doi: 10.1016/j.jep.2021.114171. Epub 2021 Apr 30.
Centaurium erythraea is an important medicinal plant in many countries, e.g. Morocco, Algeria, Italy, Spain, Portugal, and countries of Balkan Peninsula. It is used in folk medicine to treat various illnesses. It is also used as an antiapoplectic, anticoagulant, anticholagogue, antipneumonic, hematocathartic, and as a hypotensive agent.
In this review, previous reports on the taxonomy, botanical description, geographic distribution, ethnomedicinal applications, phytochemistry, pharmacological properties, and toxicity of Centaurium erythraea were critically summarized.
Scientific search engines including PubMed, ScienceDirect, SpringerLink, Web of Science, Scopus, Wiley Online, SciFinder, and Google Scholar were consulted to collect data on C. erythraea. The data presented in this work summarized the main reports on C. erythraea phytochemical compounds, ethnomedicinal uses, and pharmacological activities.
C. erythraea is used in traditional medicine to treat various diseases such as diabetes, fever, rhinitis, stomach ailments, urinary tract infections, dyspeptic complaints, loss of appetite, and hemorrhoids, and as diuretic. The essential oils and extracts of C. erythraea exhibited numerous biological properties such as antibacterial, antioxidant, antifungal, antileishmanial, anticancer, antidiabetic, anti-inflammatory, insecticidal, diuretic, gastroprotective, hepatoprotective, dermatoprotective, neuroprotective, and inhibitory agent for larval development. Phytochemical characterization of C. erythraea revealed the presence of several classes of secondary metabolites such as xanthonoids, terpenoids, flavonoids, phenolic acids, and fatty acids.
Ethnomedicinal studies demonstrated the use of C. erythraea for the treatment of various disorders. Pharmacological reports showed that C. erythraea especially its aerial parts and roots exhibited potent, and beneficial activities. These findings confirmed the link between the traditional medicinal use and the results of the scientific biological experiments. Considering these results, further investigation using diverse in vivo pharmacological assays are strongly recommended to validate the results of its traditional use. Toxicological tests and pharmacokinetic studies are also required to validate the safety and efficacy of C. erythraea and its bioactive contents.
Centaurium erythraea 是许多国家（如摩洛哥、阿尔及利亚、意大利、西班牙、葡萄牙和巴尔干半岛国家）重要的药用植物。它在民间医学中用于治疗各种疾病。它也被用作抗中风、抗凝、利胆、抗肺炎、血液泻药和降压药。
在本次综述中，批判性地总结了 Centaurium erythraea 的分类学、植物学描述、地理分布、民族医学应用、植物化学、药理学特性和毒性的先前报告。
通过查阅 PubMed、ScienceDirect、SpringerLink、Web of Science、Scopus、Wiley Online、SciFinder 和 Google Scholar 等科学搜索引擎，收集有关 Centaurium erythraea 的数据。本工作中呈现的数据总结了 Centaurium erythraea 植物化学化合物、民族医学用途和药理学活性的主要报告。
Centaurium erythraea 在传统医学中用于治疗各种疾病，如糖尿病、发热、鼻炎、胃病、尿路感染、消化不良、食欲不振和痔疮，以及作为利尿剂。Centaurium erythraea 的精油和提取物表现出多种生物特性，如抗菌、抗氧化、抗真菌、抗利什曼原虫、抗癌、抗糖尿病、抗炎、杀虫、利尿、胃保护、肝保护、皮肤保护、神经保护和幼虫发育抑制剂。Centaurium erythraea 的植物化学特征表明存在几类次生代谢物，如黄烷酮、萜类、类黄酮、酚酸和脂肪酸。
民族医学研究表明 Centaurium erythraea 可用于治疗各种疾病。药理学报告表明，Centaurium erythraea 特别是其地上部分和根具有强大且有益的活性。这些发现证实了传统药用与科学生物实验结果之间的联系。考虑到这些结果，强烈建议使用不同的体内药理学测定方法进一步研究，以验证其传统用途的结果。还需要进行毒理学试验和药代动力学研究，以验证 Centaurium erythraea 及其生物活性成分的安全性和有效性。
