Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, And Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.
Microbiology and Molecular Biology Team, Center of Plant and Microbial Biotechnology, Biodiversity and Environment, Faculty of Sciences, Mohammed V University in Rabat, Morocco.
J Ethnopharmacol. 2021 Jan 30;265:113318. doi: 10.1016/j.jep.2020.113318. Epub 2020 Aug 31.
Origanum majorana L., is an aromatic and medicinal plant distributed in different parts of Mediterranean countries. This species is widely used in traditional medicine for the treatment of many diseases such as allergies, hypertension, respiratory infections, diabetes, stomach pain, and intestinal antispasmodic.
This work reports previous studies on O. majorana concerning its taxonomy, botanical description, geographical distribution, traditional use, bioactive compounds, toxicology, and biological effects.
Different scientific data bases such as Web of Science, Scopus, Wiley Online, SciFinder, Google Scholar, PubMed, ScienceDirect, and SpringerLink were consulted to collect data about O. majorana. The presented data emphasis bioactive compounds, traditional uses, toxicological investigations, and biological activities of O. majorana.
The findings of this work marked an important correlation between the traditional use of O. majorana as an anti-allergic, antihypertensive, anti-diabetic agent, and its biological effects. Indeed, pharmacological investigations showed that essential oils and extracts from O. majorana exhibit different biological properties, particularly; antibacterial, antifungal, antioxidant, antiparasitic, antidiabetic, anticancer, nephrotoxicity protective, anti-inflammatory, analgesic and anti-pyretic, hepatoprotective, and antimutagenic effects. Toxicological evaluation confirmed the safety and innocuity of this species and supported its medicinal uses. Several bioactive compounds belonging to different chemical family such as terpenoids, flavonoids, and phenolic acids were also identified in O. majorana.
The results suggest that the pharmacological properties of O. majorana confirm its traditional uses. Indeed, O. majorana essential oils showed remarkable antimicrobial, antioxidant, anticancer, anti-inflammatory, antimutagenic, nephroprotective, and hepatoprotective activities. However, further investigations regarding the evaluation of molecular mechanisms of identified compounds against human cancer cell lines, inflammatory process, and microbial infections are needed to validate pharmacodynamic targets. The toxicological investigation of O. Majorana confirmed its safety and therefore encouraged pharmacokinetic evaluation tests to validate its bioavailability.
马郁兰（Origanum majorana L.）是一种芳香药用植物，分布在地中海国家的不同地区。该物种在传统医学中被广泛用于治疗多种疾病，如过敏、高血压、呼吸道感染、糖尿病、胃痛和肠道解痉。
本工作报道了马郁兰的先前研究，包括其分类学、植物学描述、地理分布、传统用途、生物活性化合物、毒理学和生物学效应。
通过 Web of Science、Scopus、Wiley Online、SciFinder、Google Scholar、PubMed、ScienceDirect 和 SpringerLink 等不同科学数据库检索数据，收集马郁兰的相关数据。所呈现的数据强调了马郁兰的生物活性化合物、传统用途、毒理学研究和生物学活性。
本工作的研究结果表明，马郁兰作为抗过敏、抗高血压、抗糖尿病药物的传统用途与其生物学效应之间存在重要相关性。事实上，药理学研究表明，马郁兰的精油和提取物表现出不同的生物学特性，特别是具有抗菌、抗真菌、抗氧化、抗寄生虫、抗糖尿病、抗癌、肾毒性保护、抗炎、镇痛和解热、保肝和抗突变作用。毒理学评价证实了该物种的安全性和无害性，支持其药用用途。还在马郁兰中鉴定出属于不同化学家族的几种生物活性化合物，如萜类、类黄酮和酚酸。
研究结果表明，马郁兰的药理特性证实了其传统用途。事实上，马郁兰精油表现出显著的抗菌、抗氧化、抗癌、抗炎、抗突变、肾保护和肝保护活性。然而，需要进一步研究鉴定化合物对人类癌细胞系、炎症过程和微生物感染的作用机制，以验证药效靶点。马郁兰的毒理学研究证实了其安全性，因此鼓励进行药代动力学评价试验，以验证其生物利用度。
