Toman Jakub, Pickova Darina, Brandova Karolina, Ostry Vladimir, Malir Frantisek
Department of Biology, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech Republic.
Center for Health, Nutrition and Food in Brno, National Institute of Public Health in Prague, Palackeho 3a, 61242, Brno, Czech Republic.
Drug Saf. 2025 Jun 12. doi: 10.1007/s40264-025-01570-5.
Medicinal plants are extensively utilized as dietary supplements to encourage disease prevention and to support the treatment of various health disorders. Unfortunately, several plants are known for mycotoxin contamination, which may overwhelm any beneficial effects the plants might have.
The purpose of the study was to determine the presence of ochratoxin A (OTA) and citrinin (CIT) in medicinal herbal products (MHP).
Sixty samples of different MHP types were purchased on the Czech market during 2020-2021. Both mycotoxins were determined using high-performance liquid chromatography with a fluorescence detector with immunoaffinity columns employed as a pretreatment.
In total, 40% and 27% of samples were above the limit of quantification with the concentrations ranging up to 826.62 ng/g and 472.79 ng/g for OTA and CIT, respectively. The co-occurrence was confirmed in six MHP types.
MHP could be a significant source of OTA and CIT. To protect the health of MHP users, it is desirable to continue monitoring the presence of mycotoxins in MHP. During this study, new OTA regulations for herbs came into force in the EU.
药用植物被广泛用作膳食补充剂，以促进疾病预防并支持各种健康疾病的治疗。不幸的是，几种植物因被霉菌毒素污染而闻名，这可能会抵消这些植物可能具有的任何有益效果。
本研究的目的是确定药用草药产品（MHP）中赭曲霉毒素A（OTA）和桔霉素（CIT）的存在情况。
2020年至2021年期间在捷克市场购买了60份不同类型的MHP样品。两种霉菌毒素均使用配备荧光检测器的高效液相色谱法测定，并采用免疫亲和柱进行预处理。
总体而言，40%和27%的样品超过了定量限，OTA和CIT的浓度分别高达826.62 ng/g和472.79 ng/g。在六种MHP类型中证实了两种霉菌毒素的共存。
MHP可能是OTA和CIT的重要来源。为保护MHP使用者的健康，有必要继续监测MHP中霉菌毒素的存在情况。在本研究期间，欧盟针对草药的新OTA法规生效。
