Department of Orthopaedics, University Clinic Aachen, RWTH Aachen University Clinic, Pauwellstr. 31, 52074 Aachen, Germany.
Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi SA, Italy.
Br Med Bull. 2021 Jun 10;138(1):144-154. doi: 10.1093/bmb/ldab008.
Chondral defects of the talus are common and their treatment is challenging.
Recent published literatures.
Membrane-induced Autologous Chondrocyte Implantation (mACI) and Autologous Matrix-Induced Chondrogenesis (AMIC) have been proposed as management for chondral defects of the talus.
It is debated whether AMIC provides greater outcomes compared to mACI for chondral regeneration. Several clinical studies showed controversial results, and the best treatment has not yet been clarified.
To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.
AMIC exhibits similar clinical results to mACI. However, AMIC involves one single surgical procedure, no articular cartilage harvest and hence no morbidity from it, no need for chondrocyte expansion in a separate laboratory setting. For these reasons, AMIC may be preferred to mACI.
距骨软骨缺损很常见，其治疗具有挑战性。
最近发表的文献。
膜诱导自体软骨细胞植入术（mACI）和自体基质诱导软骨形成术（AMIC）已被提议用于治疗距骨软骨缺损。
与 mACI 相比，AMIC 是否能提供更好的软骨再生效果存在争议。几项临床研究结果存在争议，最佳治疗方法尚未明确。
探讨 AMIC 在中期随访时是否比 mACI 提供更好的结果。
AMIC 与 mACI 具有相似的临床效果。然而，AMIC 只需进行一次手术，无需采集关节软骨，因此不会产生相关并发症，也无需在单独的实验室环境中进行软骨细胞扩增。基于这些原因，AMIC 可能优于 mACI。
