Charles Perkins Centre, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, D17, The Hub, Camperdown, NSW, 2006, Australia.
Boston University School of Medicine, Department of Medicine, Rheumatology and Clinical Epidemiology, USA.
Nutr Health. 2022 Jun;28(2):229-238. doi: 10.1177/02601060211011798. Epub 2021 May 4.
Data in the Offspring Framingham Osteoporosis Study (FOS) suggested that higher intake of dietary fiber was modestly protective against loss of bone mineral density at the femoral neck in men but not in women.
To examine the relationship of fiber intake with risk of hip fractures in men.
We included 367 men from the FOS Original cohort, 1730 men from the FOS Offspring cohort, and 782 men from the Concord Health and Ageing in Men Project (CHAMP) in the analysis. Incident fractures were defined as medically confirmed first occurrence of osteoporotic fractures at the proximal femur. Fiber intake was estimated via a validated food frequency questionnaire (FFQ) or diet history. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A random-effects model was used to estimate the pooled relative risk in meta-analysis.
Seventy-two incident hip fractures were identified, of which 24 occurred in the FOS Original cohort [mean (SD): age 75.3 (5.1) years; follow-up time: 8.5 (6.2) years; dietary fiber: 19 (8) (g/d)], 19 in the FOS Offspring cohort [58.8 (9.8) years; 11.0 (5.9) years; 19 (8) (g/d)], and 29 in CHAMP [81.4 (4.5) years; 5.2 (1.5) years; 28 (10) (g/d)]. We did not find significant associations within each cohort between fiber intake and risk of hip fractures. The pooled HR (95% CI) was 0.80 (0.39, 1.66) comparing energy-adjusted dietary fiber at tertile 3 vs. tertile 1 (I = 0, = 0.56).
These data suggested that dietary fiber was not associated with risk of incident hip fractures in men.
子女弗雷明汉骨质疏松研究（FOS）的数据表明，膳食纤维摄入量较高与男性股骨颈骨密度丢失适度相关，但与女性无关。
研究膳食纤维摄入量与男性髋部骨折风险的关系。
我们纳入了 FOS 原始队列的 367 名男性、FOS 子女队列的 1730 名男性和 CHAMP（男性健康和老龄化项目）的 782 名男性进行分析。骨折事件定义为经医学证实的股骨近端骨质疏松性骨折首次发生。膳食纤维摄入量通过验证后的食物频率问卷（FFQ）或饮食史进行评估。应用 Cox 比例风险模型估计危险比（HR）和 95%置信区间（CI）。使用随机效应模型进行荟萃分析以估计汇总相对风险。
共确定了 72 例髋部骨折事件，其中 24 例发生在 FOS 原始队列中[平均（SD）年龄：75.3（5.1）岁；随访时间：8.5（6.2）年；膳食纤维：19（8）（g/d）]，19 例发生在 FOS 子女队列中[58.8（9.8）岁；11.0（5.9）年；19（8）（g/d）]，29 例发生在 CHAMP 中[81.4（4.5）岁；5.2（1.5）年；28（10）（g/d）]。我们未发现每个队列中膳食纤维摄入量与髋部骨折风险之间存在显著关联。比较三分位 3 与三分位 1（I = 0， = 0.56）时，膳食纤维的汇总 HR（95%CI）为 0.80（0.39, 1.66）。
这些数据表明，膳食纤维与男性髋部骨折风险无关。
