Department of Comparative, Diagnostic, & Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Vet Clin Pathol. 2022 Feb;50 Suppl 1:76-82. doi: 10.1111/vcp.12944. Epub 2021 May 3.
A young French Bulldog was presented with clinical signs of chronic gastrointestinal disease, unresponsive to medical therapies. Parasite screenings and abdominal ultrasound failed to identify the etiology of the clinical signs. Cytologic evaluation of a rectal scraping sample diagnosed presumptive granulomatous colitis (GC) based on the presence of numerous macrophages with characteristic abundant, pink, granular cytoplasm, which showed an intense pink color when stained with periodic acid-Schiff. Tissue biopsy samples and Escherichia coli fluorescence in situ hybridization analysis confirmed the cytologic diagnosis. The cytologic, histopathologic, and clinical features and staining properties of GC in a French Bulldog are reported. Rectal scraping should be considered a part of the diagnostic evaluation in patients with suspected GC.
一只年轻的法国斗牛犬出现慢性胃肠道疾病的临床症状，对药物治疗无反应。寄生虫筛查和腹部超声未能确定临床症状的病因。直肠刮取样本的细胞学评估基于存在大量具有特征性丰富、粉红色、颗粒状细胞质的巨噬细胞，用过碘酸希夫染色时呈现强烈的粉红色，诊断为疑似肉芽肿性结肠炎（GC）。组织活检样本和大肠杆菌荧光原位杂交分析证实了细胞学诊断。报道了一只法国斗牛犬的 GC 的细胞学、组织病理学和临床特征以及染色特性。直肠刮取术应被视为疑似 GC 患者诊断评估的一部分。
