Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, 518060, P. R. China.
Chem Biodivers. 2021 Jul;18(7):e2100265. doi: 10.1002/cbdv.202100265. Epub 2021 Jun 2.
Commiphorane K (1), a new dinorditerpenoid, commiphoranes L-N (2-4), three new germacrane-type sesquiterpenoids, and commiphorane O (5), one new guaiane-type sesquiterpenoid, were isolated from Resina Commiphora. Their structures were characterized by spectroscopic and computational methods. In particular, the structure of 4 was confirmed by X-ray crystallography. Compounds 2-5 were evaluated for their anti-inflammatory activities. The result shows that compound 2 suppresses lipopolysaccharide (LPS)-stimulated production of TNF-α in RAW264.7 cells in a dose-dependent manner.
乳香烷 K（1），一种新的二萜，乳香烷 L-N（2-4），三种新的倍半萜，以及乳香烷 O（5），一种新的愈创木烷型倍半萜，从乳香树脂中分离得到。它们的结构通过光谱和计算方法进行了表征。特别是，通过 X 射线晶体学确定了 4 的结构。对化合物 2-5 进行了抗炎活性评价。结果表明，化合物 2 以剂量依赖的方式抑制 RAW264.7 细胞中脂多糖（LPS）刺激的 TNF-α 的产生。
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