Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China.
Molecules. 2019 Apr 15;24(8):1475. doi: 10.3390/molecules24081475.
Four new compounds including two new sesquiterpenoid dimers, commiphoroids () and (), a new triterpenoid (), and a new sesquiterpenoid (), along with three known terpenoids (-) were isolated from , whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds and both bear an -bridge ring and feature a plausible [4 + 2] Diels-Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined.
从 中分离得到了 4 种化合物，包括 2 种新的倍半萜二聚体 commiphoroids () 和 ()、1 种新的三萜（）和 1 种新的倍半萜（），以及 3 种已知的萜类化合物 (-)。通过 NMR 光谱、HRESIMS 和 X 射线衍射分析鉴定了它们的结构。化合物 和 都带有 -桥环，并具有合理的 [4 + 2] Diels-Alder 环加成反应。抗分枝杆菌活性表明，所有测试的化合物（200 μM）均能抑制敏感和临床多药耐药（MDR）分离株的生长。此外，还检测了分离物对人癌细胞和 THP-1 单核细胞的细胞毒性。
