肥胖对 COVID-19 的细胞和分子病理生理学的影响。

The impact of obesity on the cellular and molecular pathophysiology of COVID-19.

机构信息

Department of Immunology, Institute for Cellular and Molecular Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, South Africa.

出版信息

S Afr Med J. 2020 Dec 14;111(3):211-214. doi: 10.7196/SAMJ.2021.v111i2.15398.

DOI:10.7196/SAMJ.2021.v111i2.15398

PMID:33944741

Abstract

Emerging evidence reveals a strong association between COVID-19 and obesity in terms of disease severity, need for hospitalisation and risk of mortality. In this review, we discuss cellular and molecular mechanisms potentially contributing to the pathophysiology of COVID-19 in obese patients. Understanding the relationship between COVID-19 and obesity is pertinent for the clinical management of these patients.

摘要

新出现的证据表明，COVID-19 与肥胖在疾病严重程度、住院需求和死亡风险方面存在很强的关联。在这篇综述中，我们讨论了可能导致肥胖患者 COVID-19 病理生理学的细胞和分子机制。了解 COVID-19 和肥胖之间的关系对于这些患者的临床管理至关重要。