Phytomedicine, Natural Products, Drug and Biochemical Toxicology Group, Department of Biochemistry, Landmark University, Omu Aran, Nigeria.
Department of Biochemistry, Faculty of Sciences, Ekiti State University, Ado-Ekiti, Nigeria.
Andrologia. 2021 Aug;53(7):e14092. doi: 10.1111/and.14092. Epub 2021 May 4.
Erectile dysfunction (ED) is one of the main challenges occurring among men worldwide, and is characterised by trouble getting or keeping steady erection during sexual intercourse. Various drugs like sildenafil, a phosphodiesterase-5 inhibitor (PDE-5) are freely available in the pharmacies, though normally associated with several adverse. This study was designed to assess the molecular relations obtainable between catechin, garcinal, garcinoic acid and d-tocotrienol compounds isolated from Garcinia kola and targeted receptor linked to ED. These processes include the molecular docking of catechin, garcinal, garcinoic acid, d-tocotrienol, and sildenafil to receptor: PDE-5 via AutoDock Vina. Following the docking of catechin, garcinal, garcinoic acid and d-tocotrienol with the PDE-5-receptor protein, we observed that all are protein inhibitors with garcinoic acid showing better binding affinity -10.0 kcal/mol with PDE-5 receptor relevant to ED. Hence, the results provided insights into the development of garcinoic acid as a replacement for present ED management, with further analysis worth considering.
勃起功能障碍（ED）是全球男性面临的主要挑战之一，其特征是在性行为中难以获得或保持稳定的勃起。虽然药店有各种药物，如西地那非，一种磷酸二酯酶-5 抑制剂（PDE-5），但通常与多种不良反应相关。本研究旨在评估从可乐果中分离得到的儿茶素、garcinal、garcinoic 酸和 d-生育三烯酚化合物与 ED 相关的靶向受体之间的分子关系。这些过程包括通过 AutoDock Vina 将儿茶素、garcinal、garcinoic 酸和 d-生育三烯酚分子对接至受体：PDE-5。在将儿茶素、garcinal、garcinoic 酸和 d-生育三烯酚与 PDE-5-受体蛋白对接后，我们观察到所有这些都是蛋白抑制剂，garcinoic 酸与 PDE-5 受体的结合亲和力更好，为-10.0 kcal/mol，与 ED 相关。因此，这些结果为 garcinoic 酸作为现有 ED 管理替代物的开发提供了思路，值得进一步分析。
