Mancera-Soto Erica, Ramos-Caballero Diana Marcela, Magalhaes Jose, Chaves Gomez Sandra, Schmidt Walter F J, Cristancho-Mejía Edgar
Departamento del Movimiento Corporal Humano, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
Department of Sports Medicine and Sports Physiology, University of Bayreuth, Bayreuth, Germany.
Exp Physiol. 2021 Jul;106(7):1470-1481. doi: 10.1113/EP089433. Epub 2021 May 25.
What is the central question of this study? To what extent does testosterone influence haemoglobin formation during male puberty? What is the main finding and its importance? In boys, testosterone might be responsible for about 65% of the increase in haemoglobin mass during puberty. The underlying mechanisms are assumed to be twofold: (i) indirectly, mediated by the increase in lean body mass, and (ii) directly by immediate testosterone effects on erythropoiesis. Thereby, an increase in testosterone of 1 ng/ml is associated with an increase in haemoglobin mass of ∼65 g. These processes are likely to determine endurance performance in adulthood.
The amount of haemoglobin during puberty is related to endurance performance in adulthood. During male puberty, testosterone stimulates erythropoiesis and could therefore be used as a marker for later endurance performance. This cross-sectional study aimed to determine the relationship between serum testosterone concentration and haemoglobin mass (Hbmass) in both male and female children and adolescents and to evaluate the possible influences of altitude and training. Three-hundred and thirteen differentially trained boys and girls aged from 9 to 18 years and living at altitudes of 1000 and 2600 m above sea level entered the study. The stage of sexual maturation was determined according to the classification of Tanner. Testosterone was measured by ELISA. Hbmass was determined by CO-rebreathing. Haemoglobin concentration did not change during maturation in girls and was 11% higher during puberty in boys, while Hbmass was elevated by 33% in Tanner stage V compared to stage II in girls (498 ± 77 vs. 373 ± 88 g) and by 95% in boys (832 ± 143 vs. 428 ± 95 g). This difference can most likely be attributed to indirect testosterone influences through an increase in lean body mass (LBM) and to direct testosterone effects on erythropoiesis, which increase the Hbmass by ∼65 g per 1 ng/ml. Altitude and training statuses were not associated with testosterone, but with an increase in Hbmass (altitude by 1.1 g/kg LBM, training by 0.8 g/kg LBM). Changes in Hbmass are closely related to testosterone levels during male puberty. Further studies will show whether testosterone and Hbmass during childhood and adolescence can be used as diagnostic tools for endurance talents.
本研究的核心问题是什么？睾酮在男性青春期对血红蛋白形成的影响程度如何？主要发现及其重要性是什么？在男孩中，睾酮可能导致青春期血红蛋白量增加的约65%。潜在机制被认为有两方面：（i）间接的，由瘦体重增加介导；（ii）直接的，由睾酮对红细胞生成的即时作用。因此，睾酮每增加1纳克/毫升与血红蛋白量增加约65克相关。这些过程可能决定成年后的耐力表现。
青春期血红蛋白量与成年后的耐力表现相关。在男性青春期，睾酮刺激红细胞生成，因此可作为后期耐力表现的标志物。这项横断面研究旨在确定男童和女童及青少年血清睾酮浓度与血红蛋白量（Hbmass）之间的关系，并评估海拔和训练的可能影响。313名年龄在9至18岁、生活在海拔1000米和2600米的经过不同训练的男孩和女孩参与了研究。根据坦纳分类法确定性成熟阶段。通过酶联免疫吸附测定法测量睾酮。通过一氧化碳再呼吸法测定Hbmass。女孩在成熟过程中血红蛋白浓度未发生变化，男孩青春期时血红蛋白浓度高11%，而女孩在坦纳五期时Hbmass比二期升高33%（498±77克对373±88克），男孩升高95%（832±143克对428±95克）。这种差异很可能归因于睾酮通过瘦体重（LBM）增加产生的间接影响以及睾酮对红细胞生成的直接作用，即每1纳克/毫升使Hbmass增加约65克。海拔和训练状态与睾酮无关，但与Hbmass增加有关（海拔每增加1.1克/千克LBM，训练每增加0.8克/千克LBM）。男性青春期Hbmass的变化与睾酮水平密切相关。进一步的研究将表明儿童和青少年时期的睾酮和Hbmass是否可作为耐力天赋的诊断工具。
