Banyeh Moses, Kangkpi Thea, Bani Simon B, Zogli Kervin Edinam, Tanko Muniru Mohammed, Atuahene Peter Eugene, Iddrisu Aisha Yaaba, Ekor Christine, Akoto Emmanuel Osei, Amidu Nafiu
Department of Biomedical Laboratory Science University for Development Studies Tamale Ghana.
Health Sci Rep. 2023 Sep 4;6(9):e1547. doi: 10.1002/hsr2.1547. eCollection 2023 Sep.
There are sex differences in blood cell count and hemoglobin (HGB) in adulthood due to differences in the levels of circulating sex hormones. The second-to-fourth digit ratio (2D:4D) is the putative marker of prenatal hormone exposure. The 2D:4D or the right-left difference (Dr-l) are sexually dimorphic and are correlates of sex hormones in adulthood. The study sought to determine whether sex differences in adult blood cell count and HGB can be partly explained by the 2D:4D or Dr-l.
The study was cross-sectional between June and December 2021 at the University for Development Studies. The study involved 207 healthy participants (females = 113) aged from 18 to 32 years. The right-hand (2D:4DR), and the left-hand (2D:4DL) digit ratio and their difference (Dr-l) were measured using Computer-assisted analysis. Blood cell count, HGB, testosterone, and estradiol were measured from venous blood samples using an automated HGB analyzer and ELIZA technique.
The platelet count was inversely related to the 2D:4DR in the total sample with the 2D:4DR accounting for about 0.2% (adj = 0.002) of the variability in platelet count. However, there was a sex difference as indicated by the significant interaction between sex and the 2D:4DR on platelet count ( = 0.03). The relationship between platelet count and the 2D:4DR was negative in females but positive in males. Also, there was a positive relationship between HGB concentration and the Dr-l in the total study sample, where the Dr-l accounted for about 0.6% (adj = 0.006) of the variability in HGB concentration. Sex interacted significantly with the Dr-l on HGB concentration ( = 0.01) such that the relationship between HGB and the Dr-l was positive in females but negative in males.
Prenatal hormone exposure, as indexed by the 2D:4D ratio, may partly account for the observed sex differences in platelet count and HGB levels in adulthood.
由于循环性激素水平的差异，成年期血细胞计数和血红蛋白（HGB）存在性别差异。食指与无名指比例（2D:4D）被认为是产前激素暴露的标志物。2D:4D或左右差值（Dr-l）具有性别二态性，且与成年期性激素相关。本研究旨在确定成年期血细胞计数和HGB的性别差异是否可部分由2D:4D或Dr-l来解释。
本研究于2021年6月至12月在发展研究大学进行，为横断面研究。研究纳入了207名年龄在18至32岁之间的健康参与者（女性 = 113名）。使用计算机辅助分析测量右手（2D:4DR）和左手（2D:4DL）的手指比例及其差值（Dr-l）。使用自动HGB分析仪和酶联免疫吸附测定（ELISA）技术从静脉血样本中测量血细胞计数、HGB、睾酮和雌二醇。
在总样本中，血小板计数与2D:4DR呈负相关，2D:4DR约占血小板计数变异性的0.2%（调整后 = 0.002）。然而，性别与2D:4DR对血小板计数的显著交互作用表明存在性别差异（ = 0.03）。血小板计数与2D:4DR之间的关系在女性中为负，而在男性中为正。此外，在整个研究样本中，HGB浓度与Dr-l呈正相关，其中Dr-l约占HGB浓度变异性的0.6%（调整后 = 0.006）。性别与Dr-l对HGB浓度有显著交互作用（ = 0.01），使得HGB与Dr-l之间的关系在女性中为正，而在男性中为负。
以2D:4D比例为指标的产前激素暴露可能部分解释了成年期观察到的血小板计数和HGB水平的性别差异。
