Lopez Michele Antonio, Passarelli Pier Carmine, Godino Emmanuele, Lombardo Nicolò, Altamura Francesca Romana, Speranza Alessandro, Lopez Andrea, Papi Piero, Pompa Giorgio, D'Addona Antonio
Unit of Otolaryngology, University Campus Bio-Medico, 00128 Rome, Italy.
Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Department of Head and Neck, Catholic University of the Sacred Heart, Gemelli University Polyclinic Foundation, 00168 Rome, Italy.
Antibiotics (Basel). 2021 Apr 30;10(5):512. doi: 10.3390/antibiotics10050512.
Peri-implantitis is a pathological condition characterized by an inflammatory process involving soft and hard tissues surrounding dental implants. The management of peri-implant disease has several protocols, among which is the chemical method HYBENX. The aim of this study is to demonstrate the efficacy of HYBENX in the treatment of peri-implantitis and to compare HYBENX with other chemical agents used in the surgical treatment of peri-implantitis.
The present study included a population of ten subjects with severe peri-implantitis. The procedure used in the study involves the application of HYBENX after open-flap debridement. Each patient has been followed for 12 months after a single application of the decontaminant agent. Clinical and radiographical parameters were recorded at baseline, 3 months, and 12 months after treatment completion.
At baseline, a mean pocket probing depth (PPD) of 7.3 ± 0.5 mm and a mean clinical attachment level (CAL) of 8.8 ± 0.8 mm was recorded. An average residual PPD of 4.2 ± 0.5 mm and a mean CAL of 5.2 ± 0.8 mm were observed after 1 year. Additionally, the average of bone gain was about 3.4 mm, with a mean marginal bone level (MBL) change from 5.8 mm (baseline) to 2.4 mm (12 months). In total, 90% of the treated implants reached the success rate after the 1-year follow-up. Only in one case out of ten treated implants was resolution of the disease not achieved.
Clinical improvements highlight that the procedure of open-flap debridement (OFD) + HYBENX may be considered an effective technique in the treatment of peri-implantitis. From the results obtained, it can be concluded that the use of HYBENX in the surgical treatment of peri-implantitis is promising. Overall, this protocol demands further studies to better understand the role and potential benefits of HYBENX in the treatment of peri-implantitis.
种植体周围炎是一种病理状况，其特征为涉及牙种植体周围软组织和硬组织的炎症过程。种植体周围疾病的管理有多种方案，其中包括化学方法HYBENX。本研究的目的是证明HYBENX在治疗种植体周围炎方面的疗效，并将HYBENX与用于种植体周围炎外科治疗的其他化学剂进行比较。
本研究纳入了10名患有严重种植体周围炎的受试者。研究中使用的程序包括在翻瓣清创术后应用HYBENX。在单次应用去污剂后，对每位患者进行了12个月的随访。在治疗完成后的基线、3个月和12个月记录临床和影像学参数。
在基线时，记录的平均探诊深度（PPD）为7.3±0.5毫米，平均临床附着水平（CAL）为8.8±0.8毫米。1年后观察到平均残余PPD为4.2±0.5毫米，平均CAL为5.2±0.8毫米。此外，平均骨增量约为3.4毫米，平均边缘骨水平（MBL）从5.8毫米（基线）变化至2.4毫米（12个月）。在1年的随访后，总共90%的治疗种植体达到了成功率。在10个治疗的种植体中，只有1例未实现疾病的缓解。
临床改善表明，翻瓣清创术（OFD）+HYBENX的程序可被认为是治疗种植体周围炎的有效技术。从获得的结果可以得出结论，在种植体周围炎的外科治疗中使用HYBENX是有前景的。总体而言，该方案需要进一步研究，以更好地了解HYBENX在治疗种植体周围炎中的作用和潜在益处。
