Department of Biomedical, Odontostomatological Sciences and of Morphological and Functional Images, Unit of Periodontology, School of Dentistry, University of Messina, AOU Policlinico "G. Martino", Via Consolare Valeria 1, 98125, Messina, Italy.
Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University of Naples "Federico II", Via G. Pansini 5, 80131, Naples, Italy.
Clin Oral Investig. 2018 Mar;22(2):791-800. doi: 10.1007/s00784-017-2154-7. Epub 2017 Jun 17.
Chemotherapeutic agents have been widely used as adjuncts for the treatment of chronic periodontitis (CP). This study investigated and compared a desiccant agent as an adjunct to scaling and root planing (SRP) versus SRP alone for the treatment of CP.
Thirty-six patients with CP were studied. Using a split-mouth design, the maxillary right and left quadrants were randomly assigned to SRP plus desiccant (Hybenx® EPIEN Medical, Inc. St. Paul, MN, USA) or SRP alone. Patients were examined on a regular basis for clinical, microbiological, and inflammatory mediator changes over a 1-year period. Clinical attachment level (CAL) was the primary outcome variable. In addition, the red complex bacteria and gingival crevicular fluid (GCF) inflammatory mediators were monitored.
Compared to baseline, both treatments demonstrated an improvement in periodontal parameters. Compared to SRP alone, SRP plus desiccant yielded a significant improvement in probing depth (PD) (SRP: 2.23 ± 0.31 mm vs. desiccant: 3.25 ± 0.57 mm, p < 0.05), CAL (SRP: 3.16 ± 0.29 mm vs. desiccant: 4.21 ± 0.34 mm, p < 0.05 mm) and bleeding on probing (BOP) (SRP: 4.56 ± 1.5% vs. desiccant: 34.23 ± 4.2%, p < 0.001) at 12 months. Similarly, in the SRP plus desiccant group, the bacteria of the red complex were significantly reduced (p < 0.05); and the level of inflammatory mediators was significantly reduced (p < 0.003) compared to SRP alone.
SRP plus the desiccant resulted in a greater reduction in clinical, microbial and inflammatory mediators compared to SRP alone.
Desiccant, when combined to SRP, was demonstrated as a significant approach to control the levels of certain periodontal pathogens, inflammatory mediators in patients with CP.
化学药物已被广泛用作慢性牙周炎（CP）治疗的辅助手段。本研究调查并比较了干燥剂作为牙周刮治和根面平整（SRP）辅助手段与单独 SRP 相比治疗 CP 的效果。
研究了 36 名 CP 患者。采用分口设计，上颌左右象限随机分为 SRP 加干燥剂（Hybenx® EPIEN Medical，Inc. St. Paul，MN，USA）或单独 SRP。患者在 1 年内定期接受检查，以观察临床、微生物和炎症介质变化。临床附着水平（CAL）是主要观察指标。此外，还监测了红色复合体细菌和龈沟液（GCF）炎症介质。
与基线相比，两种治疗方法均改善了牙周参数。与单独 SRP 相比，SRP 加干燥剂在探诊深度（PD）（SRP：2.23±0.31mm 比干燥剂：3.25±0.57mm，p<0.05）、CAL（SRP：3.16±0.29mm 比干燥剂：4.21±0.34mm，p<0.05mm）和探诊出血（BOP）（SRP：4.56±1.5%比干燥剂：34.23±4.2%，p<0.001）方面均有显著改善，12 个月时。同样，在 SRP 加干燥剂组中，红色复合体细菌显著减少（p<0.05）；炎症介质水平也显著降低（p<0.003），与单独 SRP 相比。
与单独 SRP 相比，SRP 加干燥剂可更显著降低临床、微生物和炎症介质水平。
干燥剂联合 SRP 被证明是一种控制 CP 患者某些牙周病原体和炎症介质水平的有效方法。
