Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Biodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Int J Mol Sci. 2021 Apr 30;22(9):4793. doi: 10.3390/ijms22094793.
Mitochondria are the major source of intercellular bioenergy in the form of ATP. They are necessary for cell survival and play many essential roles such as maintaining calcium homeostasis, body temperature, regulation of metabolism and apoptosis. Mitochondrial dysfunction has been observed in variety of diseases such as cardiovascular disease, aging, type 2 diabetes, cancer and degenerative brain disease. In other words, the interpretation and regulation of mitochondrial signals has the potential to be applied as a treatment for various diseases caused by mitochondrial disorders. In recent years, mitochondrial transplantation has increasingly been a topic of interest as an innovative strategy for the treatment of mitochondrial diseases by augmentation and replacement of mitochondria. In this review, we focus on diseases that are associated with mitochondrial dysfunction and highlight studies related to the rescue of tissue-specific mitochondrial disorders. We firmly believe that mitochondrial transplantation is an optimistic therapeutic approach in finding a potentially valuable treatment for a variety of mitochondrial diseases.
线粒体是细胞内生物能量的主要来源，形式为 ATP。它们是细胞存活所必需的，发挥着许多重要作用，如维持钙稳态、体温、调节代谢和细胞凋亡。线粒体功能障碍在多种疾病中都有观察到，如心血管疾病、衰老、2 型糖尿病、癌症和退行性脑疾病。换句话说，线粒体信号的解读和调控有可能作为治疗由线粒体紊乱引起的各种疾病的手段。近年来，线粒体移植作为一种通过增加和替换线粒体来治疗线粒体疾病的创新策略，越来越受到关注。在这篇综述中，我们关注与线粒体功能障碍相关的疾病，并重点介绍与组织特异性线粒体疾病的拯救相关的研究。我们坚信，线粒体移植是一种乐观的治疗方法，有望为多种线粒体疾病找到有价值的治疗方法。
