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欧洲海鲈自然感染期间皮肤免疫反应和微生物群的改变()。 （注：括号内内容原文缺失）

Alteration of the Immune Response and the Microbiota of the Skin during a Natural Infection by in European Seabass ().

作者信息

Cámara-Ruiz María, Cerezo Isabel M, Guardiola Francisco A, García-Beltrán José María, Balebona M Carmen, Moriñigo Miguel Ángel, Esteban María Ángeles

机构信息

Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.

Departamento de Microbiología, Universidad de Málaga, 29071 Málaga, Spain.

出版信息

Microorganisms. 2021 Apr 29;9(5):964. doi: 10.3390/microorganisms9050964.

DOI:10.3390/microorganisms9050964
PMID:33947022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8146741/
Abstract

Disease outbreaks continue to represent one of the main bottlenecks for the sustainable development of the aquaculture industry. In marine aquaculture, many species from the genus are serious opportunistic pathogens responsible for significant losses to producers. In this study, the effects on the immune response and the skin microbiota of European sea bass () were studied after a natural disease outbreak caused by . Data obtained from infected and non-infected fish were studied and compared. Regarding the local immune response (skin mucus) a decrease in the protease activity was observed in infected fish. Meanwhile, at a systemic level, a decrease in protease and lysozyme activity was reported while peroxidase activity showed a significant increase in serum from infected fish. A clear dysbiosis was observed in the skin mucus microbiota of infected fish in comparison with non-infected fish. Moreover, , was identified as a biomarker for the infected group and for healthy fish. This study highlights the importance of characterizing the mucosal surfaces and microbial composition of the skin mucus (as a non-invasive technique) to detect potential disease outbreaks in fish farms.

摘要

疾病爆发仍然是水产养殖业可持续发展的主要瓶颈之一。在海水养殖中，该属的许多物种是严重的机会性病原体，给养殖户造成重大损失。在本研究中，研究了由[病原体名称未给出]引起的自然疾病爆发后，对欧洲海鲈（[物种名称未给出]）免疫反应和皮肤微生物群的影响。对感染和未感染鱼类的数据进行了研究和比较。关于局部免疫反应（皮肤黏液），在感染鱼类中观察到蛋白酶活性降低。同时，在系统水平上，报告显示感染鱼类血清中的蛋白酶和溶菌酶活性降低，而过氧化物酶活性显著增加。与未感染鱼类相比，感染鱼类的皮肤黏液微生物群出现明显的生态失调。此外，[生物标志物名称未给出]被确定为感染组的生物标志物，[生物标志物名称未给出]为健康鱼类的生物标志物。本研究强调了表征皮肤黏液的黏膜表面和微生物组成（作为一种非侵入性技术）对于检测养鱼场潜在疾病爆发的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/e02d3dac3899/microorganisms-09-00964-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/ac2da0d21f7a/microorganisms-09-00964-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/8015af5cecae/microorganisms-09-00964-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/32bb5e11f173/microorganisms-09-00964-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/6e4e59c7349d/microorganisms-09-00964-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/0cfe9efa7a39/microorganisms-09-00964-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/59021ba9d375/microorganisms-09-00964-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/8065a36571e7/microorganisms-09-00964-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/c54ef8f9c442/microorganisms-09-00964-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/dba9d34c579f/microorganisms-09-00964-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/04f267d9f939/microorganisms-09-00964-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/e02d3dac3899/microorganisms-09-00964-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/ac2da0d21f7a/microorganisms-09-00964-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/8015af5cecae/microorganisms-09-00964-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/32bb5e11f173/microorganisms-09-00964-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/6e4e59c7349d/microorganisms-09-00964-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/0cfe9efa7a39/microorganisms-09-00964-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/59021ba9d375/microorganisms-09-00964-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/8065a36571e7/microorganisms-09-00964-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/c54ef8f9c442/microorganisms-09-00964-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/dba9d34c579f/microorganisms-09-00964-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/04f267d9f939/microorganisms-09-00964-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad8/8146741/e02d3dac3899/microorganisms-09-00964-g011.jpg

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