Longère Benjamin, Pagniez Julien, Coisne Augustin, Farah Hedi, Schmidt Michaela, Forman Christoph, Silvestri Valentina, Simeone Arianna, Gkizas Christos V, Hennicaux Justin, Cheasty Emma, Toupin Solenn, Montaigne David, Pontana François
University of Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1011-European Genomic Institute for Diabetes (EGID), F-59000 Lille, France.
CHU Lille, Department of Cardiovascular Radiology, F-59000 Lille, France.
J Clin Med. 2021 Apr 29;10(9):1930. doi: 10.3390/jcm10091930.
To evaluate the reliability of compressed-sensing (CS) real-time single-breath-hold cine imaging for quantification of right ventricular (RV) function and volumes in congenital heart disease (CHD) patients in comparison with the standard multi-breath-hold technique.
Sixty-one consecutive CHD patients (mean age = 22.2 ± 9.0 (SD) years) were prospectively evaluated during either the initial work-up or after repair. For each patient, two series of cine images were acquired: first, the reference segmented multi-breath-hold steady-state free-precession sequence (SSFP), including a short-axis stack, one four-chamber slice, and one long-axis slice; then, an additional real-time compressed-sensing single-breath-hold sequence (CS) providing the same slices. Two radiologists independently assessed the image quality and RV volumes for both techniques, which were compared using the Wilcoxon test and paired Student's test, Bland-Altman, and linear regression analyses. The visualization of wall-motion disorders and tricuspid-regurgitation-related signal voids were also analyzed.
The mean acquisition time for CS was 22.4 ± 6.2 (SD) s (95% CI: 20.8-23.9 s) versus 442.2 ± 89.9 (SD) s (95% CI: 419.2-465.2 s) for SSFP ( < 0.001). The image quality of CS was diagnostic in all examinations and was mostly rated as good ( = 49/61; 80.3%). There was a high correlation between SSFP and CS images regarding RV ejection fraction (49.8 ± 7.8 (SD)% (95% CI: 47.8-51.8%) versus 48.7 ± 8.6 (SD)% (95% CI: 46.5-50.9%), respectively; = 0.94) and RV end-diastolic volume (192.9 ± 60.1 (SD) mL (95% CI: 177.5-208.3 mL) versus 194.9 ± 62.1 (SD) mL (95% CI: 179.0-210.8 mL), respectively; = 0.98). In CS images, tricuspid-regurgitation and wall-motion disorder visualization was good (area under receiver operating characteristic curve (AUC) = 0.87) and excellent (AUC = 1), respectively.
Compressed-sensing real-time cine imaging enables, in one breath hold, an accurate assessment of RV function and volumes in CHD patients in comparison with standard SSFP, allowing a substantial improvement in time efficiency.
与标准的多次屏气技术相比，评估压缩感知（CS）实时单次屏气电影成像用于先天性心脏病（CHD）患者右心室（RV）功能及容积定量分析的可靠性。
前瞻性评估61例连续的CHD患者（平均年龄=22.2±9.0（标准差）岁），这些患者处于初始检查阶段或修复术后。对每位患者采集两组电影图像：首先，参考分段多次屏气稳态自由进动序列（SSFP），包括短轴堆栈、一个四腔心层面和一个长轴层面；然后，采集提供相同层面的额外实时压缩感知单次屏气序列（CS）。两名放射科医生独立评估两种技术的图像质量和RV容积，使用Wilcoxon检验、配对t检验、Bland-Altman分析和线性回归分析进行比较。还分析了室壁运动障碍和三尖瓣反流相关信号缺失的可视化情况。
CS的平均采集时间为22.4±6.2（标准差）秒（95%可信区间：20.8 - 23.9秒），而SSFP为442.2±89.9（标准差）秒（95%可信区间：419.2 - 465.2秒）（P<0.001）。CS的图像质量在所有检查中均具有诊断价值，且大多被评为良好（n = 49/61；80.3%）。关于RV射血分数，SSFP和CS图像之间存在高度相关性（分别为49.8±7.8（标准差）%（95%可信区间：47.8 - 51.8%）和48.7±8.6（标准差）%（95%可信区间：46.5 - 50.9%）；r = 0.94），以及RV舒张末期容积（分别为192.9±60.1（标准差）毫升（95%可信区间：177.5 - 208.3毫升）和194.9±62.1（标准差）毫升（95%可信区间：179.0 - 210.8毫升）；r = 0.98）。在CS图像中，三尖瓣反流和室壁运动障碍的可视化效果分别良好（受试者操作特征曲线下面积（AUC）= 0.87）和极佳（AUC = 1）。
与标准的SSFP相比，压缩感知实时电影成像能够在单次屏气时准确评估CHD患者的RV功能及容积，使时间效率得到显著提高。
