Wang Fuyan, Pu Cailing, Ma Siying, Zhou Junjie, Jiang Yangyang, Yu Feidan, Zhang Shuheng, Wu Yan, Zhang Lingjie, He Chengbin, Hu Hongjie
Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
United Imaging Healthcare, Shanghai, China.
Front Cardiovasc Med. 2024 Jan 29;11:1286271. doi: 10.3389/fcvm.2024.1286271. eCollection 2024.
Due to its potential to significantly reduce scanning time while delivering accurate results for cardiac volume function, compressed sensing (CS) has gained traction in cardiovascular magnetic resonance (CMR) cine. However, further investigation is necessary to explore its feasibility and impact on myocardial strain results.
A total of 102 participants [75 men, 46.5 ± 17.1 (SD) years] were included in this study. Each patient underwent four consecutive cine sequences with the same slice localization, including the reference multi-breath-hold balanced steady-state free precession (bSSFP) cine, the CS cine with the same flip angle as bSSFP before (CS) and after (eCS) contrast enhancement, and the CS cine (eCS with a 70-degree flip angle after contrast enhancement. Biventricular strain parameters were derived from cine images. Two-tailed paired t-tests were used for data analysis.
Global radial strain (GRS), global circumferential strain (GCS), and global longitudinal strain (GLS) were observed to be significantly lower in comparison to those obtained from bSSFP sequences for both the right and left ventricles (all < 0.001). No significant difference was observed on biventricular GRS-LAX (long-axis) and GLS values derived from enhanced and unenhanced CS cine sequences with the same flip angle, but remarkable reductions were noted in GRS-SAX (short-axis) and GCS values ( < 0.001). After contrast injection, a larger flip angle caused a significant elevation in left ventricular strain results ( < 0.001) but did not affect the right ventricle. The increase in flip angle appeared to compensate for contrast agent affection on left ventricular GRS-SAX, GCS values, and right ventricular GRS-LAX, GLS values.
Despite incorporating gadolinium contrast agents and applying larger flip angles, single breath-hold CS cine sequences consistently yielded diminished strain values for both ventricles when compared with conventional cine sequences. Prior to employing this single breath-hold CS cine sequence to refine the clinical CMR examination procedure, it is crucial to consider its impact on myocardial strain results.
由于压缩感知（CS）在提供心脏容积功能准确结果的同时具有显著缩短扫描时间的潜力，其在心血管磁共振（CMR）电影成像中受到了关注。然而，有必要进一步研究其可行性以及对心肌应变结果的影响。
本研究共纳入102名参与者[75名男性，46.5±17.1（标准差）岁]。每位患者接受了四个连续的电影序列，这些序列具有相同的层面定位，包括参考多屏气平衡稳态自由进动（bSSFP）电影序列、与增强前（CS）和增强后（eCS）bSSFP具有相同翻转角的CS电影序列，以及增强后具有70度翻转角的CS电影序列（eCS）。双心室应变参数从电影图像中得出。采用双侧配对t检验进行数据分析。
观察到，与从bSSFP序列获得的结果相比，右心室和左心室的整体径向应变（GRS）、整体圆周应变（GCS）和整体纵向应变（GLS）均显著降低（均P<0.001）。从具有相同翻转角的增强和未增强CS电影序列得出的双心室GRS-LAX（长轴）和GLS值未观察到显著差异，但GRS-SAX（短轴）和GCS值显著降低（P<0.001）。注射造影剂后，较大的翻转角导致左心室应变结果显著升高（P<0.001），但对右心室无影响。翻转角的增加似乎补偿了造影剂对左心室GRS-SAX、GCS值以及右心室GRS-LAX、GLS值的影响。
尽管使用了钆造影剂并应用了较大的翻转角，但与传统电影序列相比，单次屏气CS电影序列始终产生较低的双心室应变值。在采用这种单次屏气CS电影序列优化临床CMR检查程序之前，考虑其对心肌应变结果的影响至关重要。
