Rossi Barbara, Esteban Maria Angéles, García-Beltran José María, Giovagnoni Giulia, Cuesta Alberto, Piva Andrea, Grilli Ester
Vetagro SpA, 42124 Reggio Emilia, Italy.
Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain.
Microorganisms. 2021 Apr 29;9(5):966. doi: 10.3390/microorganisms9050966.
Vibrosis is one of the major threats in aquaculture farming, and due to the increasing antimicrobial resistance of different species, there is an urgent need to replace conventional treatments with more sustainable solutions. Antimicrobial molecules such as organic acids (OA) and nature-identical compounds (NIC) are currently finding a central role in the infection management of terrestrial livestock, but little is known about their usage in aquaculture. The aim of this study was to perform a preliminary screening of the in vitro antimicrobial activity of a wide panel of OA and NIC against 2 species characteristic of the Mediterranean area, and , through minimal inhibitory/bactericidal concentration tests. The active principles that showed the best effective pathogen control were medium-chain fatty acids, sorbic and benzoic acid among OA and phenolic monoterpenoids (thymol, carvacrol and eugenol) and aromatic monoterpene aldehydes (vanillin and cinnamaldehyde) among NIC. These results showed how the usage of OA and NIC can open promising perspectives in terms of spp. load control in aquaculture. Natural or nature-identical feed additives can make aquaculture production not only more efficient by reducing the need for medicated treatments, but also more sustainable.
弧菌病是水产养殖中的主要威胁之一，由于不同物种的抗菌耐药性不断增加，迫切需要用更可持续的解决方案取代传统治疗方法。抗菌分子，如有机酸（OA）和天然等同化合物（NIC），目前在陆地家畜的感染管理中发挥着核心作用，但它们在水产养殖中的使用情况却鲜为人知。本研究的目的是通过最低抑菌/杀菌浓度试验，对一系列OA和NIC对地中海地区特有的两种弧菌的体外抗菌活性进行初步筛选。在OA中，表现出最佳有效病原体控制效果的活性成分是中链脂肪酸、山梨酸和苯甲酸；在NIC中，是酚类单萜（百里香酚、香芹酚和丁香酚）和芳香单萜醛（香草醛和肉桂醛）。这些结果表明，OA和NIC的使用在控制水产养殖中弧菌属的负荷方面可以开辟有前景的前景。天然或天然等同的饲料添加剂不仅可以通过减少药物治疗的需求使水产养殖生产更高效，而且更具可持续性。
