Kermanshah University of Medical Sciences, Kermanshah, Iran.
Int J Low Extrem Wounds. 2021 Sep;20(3):272-281. doi: 10.1177/1534734620921589. Epub 2020 Jun 5.
Skin burn is a major health problem in the community and seeking new and suitable treatment is suggested. In this regard, traditional remedies were consider in many countries. Regarding clinical application of herbal medicine in the healing of burn wounds, the present study was designed to evaluate the effect of ( L) extract with milk-cream on the healing of second-degree burn in a rat model. Thirty-six male Wistar rats (220 ± 30 g) were divided into 3 groups (n = 12), after establishment of second-degree burn: group1, were left without any intervention; group 2, were treated topically with silver sulfadiazine; and group 3, were treated with L extract composite with milk-cream once a day for 21 days. Macroscopically and histological examinations were conducted on 7, 14, and 21 days of therapy. Data analyses were done using 1-way analysis of variance and post hoc Tukey tests. Macroscopically, evaluation of wounds' sizes on the 14th and 21st days indicated that the wound surface was reduced significantly ( < .001) in group 3 compared with groups 1 and 2. Histological findings also showed that burn healing was significantly improved in group 3 compared with the other groups. L extract composite with milk-cream has an effective role on healing of second-degree burn in rat skin and it could a complementary and/or alternative medicine in wound healing.
皮肤烧伤是社区中的一个主要健康问题，建议寻找新的合适的治疗方法。在这方面，许多国家都考虑使用传统的补救措施。关于草药在烧伤伤口愈合中的临床应用，本研究旨在评估 (L) 提取物与奶霜对大鼠二度烧伤愈合的影响。
将 36 只雄性 Wistar 大鼠（220±30g）分为 3 组（n=12），建立二度烧伤后：第 1 组，不进行任何干预；第 2 组，局部用磺胺嘧啶银治疗；第 3 组，每天用 (L) 提取物复合奶霜治疗一次，共 21 天。在治疗的第 7、14 和 21 天进行宏观和组织学检查。使用单向方差分析和事后 Tukey 检验进行数据分析。
宏观上，第 14 天和第 21 天对伤口大小的评估表明，与第 1 组和第 2 组相比，第 3 组的伤口表面明显减少（<0.001）。组织学发现还表明，与其他组相比，第 3 组的烧伤愈合明显改善。
(L) 提取物复合奶霜对大鼠皮肤二度烧伤的愈合有显著作用，可作为创伤愈合的补充和/或替代药物。
