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芝麻油、樟脑和蜂蜜对大鼠二度烧伤创面的愈合作用

The Healing Effect of Sesame Oil, Camphor and Honey on Second Degree Burn Wounds in Rat.

作者信息

Vaghardoost Reza, Mousavi Majd Seyed GholamReza, Tebyanian Hamid, Babavalian Hamid, Malaei Leila, Niazi Mitra, Javdani Ali

机构信息

Shahid Motahari Burn Hospital, Iran University of Medical Sciences, Tehran, Iran.

Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

出版信息

World J Plast Surg. 2018 Jan;7(1):67-71.

PMID:29651394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5890368/
Abstract

BACKGROUND

Many studies were carried out to improve sophisticated dressings to accelerate healing processes and reduce the microbial burden in burn wounds. This study evaluated the healing effect of herbal ointment containing extract of sesame oil, camphor and honey on second degree burn wounds in rats in comparison with daily dressing oil vaseline.

METHODS

Forty rats were randomly assigned to two equal groups. A deep second degree burn was formed on the back of each rat with using a standard burning technique. The burns were dressed daily with herbal ointment containing extract of sesame oil, camphor and honey in group 1, dressing oil vaseline in group 2. The response to treatment was evaluated by digital photography during the treatment on 0, 7, 14, 21, 28 days. Histological scoring was undertaken for scar tissue samples on 0, 7, 14, 21, 28 days.

RESULTS

Considerable epithelization in the herbal ointment group vs. the control group over the study period was noted. Neovascularization was significantly higher in herbal ointment treated rats as well. In terms of difference of wound surface area, maximal healing was noticed in herbal ointment extract of sesame oil, camphor and honey group and the minimal repair in the control group.

CONCLUSION

The greatest rate of healing was in the herbal ointment group containing sesame oil, camphor and honey, so the herbal ointment as a suitable substitute for dressing and healing of burn wound injuries is recommended.

摘要

背景

开展了许多研究以改进精密敷料，以加速愈合过程并减少烧伤创面的微生物负荷。本研究评估了含有芝麻油、樟脑和蜂蜜提取物的草药软膏对大鼠二度烧伤创面的愈合效果，并与每日使用的凡士林油敷料进行比较。

方法

40只大鼠随机分为两组，每组数量相等。采用标准烧伤技术在每只大鼠背部造成深二度烧伤。第1组大鼠的烧伤创面每日用含有芝麻油、樟脑和蜂蜜提取物的草药软膏包扎，第2组用凡士林油敷料包扎。在治疗的第0、7、14、21、28天通过数码摄影评估治疗反应。在第0、7、14、21、28天对瘢痕组织样本进行组织学评分。

结果

在研究期间，草药软膏组与对照组相比有明显的上皮形成。草药软膏治疗的大鼠血管生成也明显更高。就创面面积差异而言，芝麻油、樟脑和蜂蜜草药软膏提取物组愈合程度最大，对照组修复程度最小。

结论

含芝麻油、樟脑和蜂蜜的草药软膏组愈合速度最快，因此推荐将该草药软膏作为烧伤创面敷料和愈合的合适替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/e9bdbe294363/wjps-7-067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/99473e9f9ce7/wjps-7-067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/ecb05980aae8/wjps-7-067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/c443919a77b9/wjps-7-067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/e9bdbe294363/wjps-7-067-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/99473e9f9ce7/wjps-7-067-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/ecb05980aae8/wjps-7-067-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/c443919a77b9/wjps-7-067-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61e4/5890368/e9bdbe294363/wjps-7-067-g004.jpg

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