Logan E F, Pearson G R, McNulty M S
Vet Rec. 1977 Nov 26;101(22):443-6. doi: 10.1136/vr.101.22.443.
Eight newborn calves were challenged orally with a known enteropathogenic strain of Escherichia coli 0101 K?(A) and two to six hours later each calf was fed a minimum of three pints colostrum. All calves suffered from acute diarrhoea of varying severity within 24 to 48 hours of infection. Immunofluorescent and histological examination of the small intestine demonstrated adherence of the challenge organism to the epithelium and the presence of pathological lesions similar to those seen in colostrum-deprived calves with enteric colibacillosis. It was concluded that in order to be effective prophylactically, colostrum must be fed prior to infection.
八头新生小牛经口接种已知的致病性大肠杆菌O101 K？（A）菌株，两至六小时后，每头小牛至少喂食三品脱初乳。所有小牛在感染后24至48小时内均出现不同程度的急性腹泻。对小肠进行免疫荧光和组织学检查发现，攻击菌附着于上皮细胞，且存在与初乳缺乏型犊牛肠型大肠杆菌病相似的病理损伤。得出的结论是，为了起到有效的预防作用，必须在感染前喂食初乳。
