Radiology Department at the Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Academic Medical Center (AMC), Amsterdam, The Netherlands.
Phys Med. 2019 Jan;57:47-57. doi: 10.1016/j.ejmp.2018.11.015. Epub 2018 Dec 20.
To design a 3D printed anthropomorphic lung vessel phantom for CT image quality assessment and to evaluate the phantom image and dose characteristics.
An in-house algorithm generated a vessel tree model, based on human lungs anatomy, which was 3D printed using a multi jet modeling printer (0.25 mm ≤ vessel diameters ≤ 8.25 mm) and inserted in an elliptical holder (thorax surrogate). The phantom was scanned (Toshiba Aquilion Genesis CT) and compared in terms of attenuation (Hounsfield units, HU) and dose characteristics with studies of five patients (normal BMI) and a commercial torso phantom, performed with the same thorax protocol. The pixel value distribution in the lung area was assessed with histograms. To investigate the adjustment of tube current modulation, tube load and CTDI were compared.
The histogram peaks for respectively vessels and surrounding tissue were at 105 HU and -985 HU (3D printed phantom), at -25 HU and -1000 HU (torso phantom) and at 25 HU and -875 HU (average patient). The contrast between vessels and surrounding was -1090 HU (3D printed), -975 HU (torso phantom), and -900 HU (average patient). The measured HU values (soft tissue and vertebra) were (32 ± 15) HU and (210 ± 71) HU (average patient); (4 ± 4) HU, (390 ± 39) HU (torso phantom) and (119 ± 5) HU, (951 ± 31) HU (3D printed phantom and holder). CTDIvol was (1.9 ± 4.7 mGy) for patients, 1.9 mGy for the torso phantom and 2.1 mGy for the 3D printed lung phantom.
An anthropomorphic 3D printed lung phantom was developed and its CT image and dose characteristics evaluated. The phantom has the potential to provide clinically relevant and reproducible measures of CT image quality.
设计一种用于 CT 图像质量评估的 3D 打印人体肺部血管模型，并评估该模型的图像和剂量特性。
基于人体肺部解剖结构，使用多喷头建模打印机（血管直径 0.25mm≤≤8.25mm）生成血管树模型，将其 3D 打印并插入椭圆形支架（胸腔替代物）中。使用东芝 Aquilion Genesis CT 对该模型进行扫描，并与五名正常体重指数患者和商用体模的研究进行比较，比较内容包括衰减（亨氏单位，HU）和剂量特性。通过直方图评估肺部区域的像素值分布。为了研究管电流调制的调整，比较了管负荷和 CTDI。
血管和周围组织的直方图峰值分别为 105HU 和-985HU（3D 打印模型）、-25HU 和-1000HU（体模）和 25HU 和-875HU（平均患者）。血管和周围组织的对比度分别为-1090HU（3D 打印模型）、-975HU（体模）和-900HU（平均患者）。测量的 HU 值（软组织和椎骨）分别为（32±15）HU 和（210±71）HU（平均患者）；（4±4）HU、（390±39）HU（体模）和（119±5）HU、（951±31）HU（3D 打印模型和支架）。患者的 CTDIvol 为（1.9±4.7）mGy，体模为 1.9mGy，3D 打印肺模型为 2.1mGy。
开发了一种人体 3D 打印肺部血管模型，并对其 CT 图像和剂量特性进行了评估。该模型具有提供与临床相关且可重复的 CT 图像质量评估的潜力。
