Mayo Clinic, Jacksonville, FL, USA.
J Prim Care Community Health. 2021 Jan-Dec;12:21501327211014087. doi: 10.1177/21501327211014087.
is the most common infection in the world and is associated with gastrointestinal and extra-gastrointestinal manifestations, including peptic ulcer disease, gastrointestinal bleeding, and lymphoproliferative disorders. Despite being discovered less than half a century ago, antibiotic resistance, exacerbated by medication non-adherence and inefficacy of proton pump inhibitors, has grown substantially, explaining the rising incidence of refractory infection. In this review, we discuss risk factors, treatment options, surveillance and follow-up, as well as emerging therapies for refractory .
是世界上最常见的感染之一，与胃肠道和胃肠道外表现有关，包括消化性溃疡病、胃肠道出血和淋巴增生性疾病。尽管这种感染在不到半个世纪前才被发现，但由于药物不依从和质子泵抑制剂无效导致的抗生素耐药性已经大大增加，这解释了难治性感染发病率的上升。在这篇综述中，我们讨论了难治性感染的危险因素、治疗选择、监测和随访，以及新出现的治疗方法。
