Batterjee Medical College, Preparatory Year Program, Jeddah, Saudi Arabia.
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Nat Prod Res. 2022 Oct;36(19):5108-5123. doi: 10.1080/14786419.2021.1919105. Epub 2021 May 5.
species (Chaetomiaceae) are a wealthy source of enzymes such as laccases, cutinases, glucuronoyl esterases, feruloyl esterases, 1,4-β-endoglucanase and lytic polysaccharide monooxygenases that reported to have various biotechnological and industrial applications in dye decolorization, bio-refinery, biomass utilization, ester biosynthesis and biodegradation. Different metabolites have been reported from this genus as depsides, azaphilones, pyrazines, naphthodianthrones and anthraquinones derivatives. These metabolites have attracted research interest due to their fascinating structures and diverse bioactivities, including antimicrobial, cytotoxic, antioxidant, anti-diabetic, and superoxide anion generation, phospholipase, prostaglandins synthesis and proteasome inhibitory activities. Therefore, these compounds can be taken into account as candidates for the development of effective and novel pharmaceutical leads. The current review represents the relevant information for the genus, in particular, its phytoconstituents and their pharmacological activities, as well as the biotechnological applications of species published from 1981 till now. More than 40 metabolites are described and - 71 references are cited. [Formula: see text].
该属物种（毛壳菌科）是丰富的酶源，如漆酶、角质酶、葡萄糖醛酸酯酶、阿魏酸酯酶、1,4-β-内切葡聚糖酶和溶菌多糖单加氧酶，据报道，这些酶具有各种生物技术和工业应用，如染料脱色、生物炼制、生物质利用、酯类生物合成和生物降解。该属还报道了不同的代谢物，如二聚体、氮杂菲酮、吡嗪、萘并二蒽酮和蒽醌衍生物。这些代谢物因其迷人的结构和多样的生物活性而引起了研究兴趣，包括抗菌、细胞毒性、抗氧化、抗糖尿病和超氧阴离子生成、磷脂酶、前列腺素合成和蛋白酶体抑制活性。因此，这些化合物可以被视为开发有效和新型药物先导物的候选物。目前的综述代表了该属的相关信息，特别是其植物成分及其药理活性，以及自 1981 年以来该属物种的生物技术应用。描述了超过 40 种代谢物，并引用了 71 篇参考文献。
