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真菌 Humicola 属的天然产物:多样性、生物活性和工业重要性。

Natural Products of the Fungal Genus Humicola: Diversity, Biological Activity, and Industrial Importance.

机构信息

Batterjee Medical College, North Obhur, Prince Abdullah Al-Faisal Street, P.O. Box 6231, Jeddah, 21442, Saudi Arabia.

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.

出版信息

Curr Microbiol. 2021 Jul;78(7):2488-2509. doi: 10.1007/s00284-021-02533-6. Epub 2021 May 18.

Abstract

Fungal metabolites are worthily taken into account as a pool of synthetically interesting and remarkably important new lead compounds for medical, agricultural, and chemical industries. Humicola species are known to have biotechnological and industrial potentials. Humicola genus (family Chaetomiaceae) is a prosperous fountainhead of unique and structurally diverse metabolites that have various bioactivities. Moreover, Humicola species attract substantial attention for their marked ability to produce thermostable enzymes with biotechnological and industrial importance. This review highlights the published researches on the isolated metabolites from the genus Humicola and their biological activities as well as the industrial importance of Humicola species. In the current review, more than 50 compounds are described and 84 references are cited.

摘要

真菌代谢产物是医学、农业和化学工业中具有合成意义和重要性的新型先导化合物的重要来源,值得关注。众所周知,高温放线菌属具有生物技术和工业潜力。高温放线菌属(毛壳菌科)是独特且结构多样的代谢产物的丰富源泉,具有多种生物活性。此外,高温放线菌属由于其显著的产生具有生物技术和工业重要性的热稳定酶的能力而引起了广泛关注。本综述重点介绍了从高温放线菌属中分离得到的代谢产物及其生物活性的研究进展,以及高温放线菌属的工业重要性。在本综述中,描述了 50 多种化合物,并引用了 84 篇参考文献。

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