Department of Plastic and Reconstructive Surgery, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.
Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea.
Biomater Sci. 2021 May 4;9(9):3425-3432. doi: 10.1039/d0bm02215b.
A synthetic zwitterionic dopamine derivative (ZW-DOPA) containing both catechol and amine groups was recently shown to exhibit excellent antifouling activity on marine surfaces. Here, we have extended these analyses to investigate the effects of ZW-DOPA coating on silicone implants. Successful formation of ZW-DOPA coatings on silicone implants was confirmed based on a combination of decreased static water contact angles on silicone implants, evidence of new peaks at 400.2 (N 1s), 232.2 (S 2s), and 168.0 (S 2p) eV, and increased quantitative atomic composition of C 1s with a concurrent decrease of Si 2p. Anti-biofilm formation assays revealed that ZW-DOPA coating prevented biofilm formation on silicone at a non-lethal concentration (0.5 mg mL-1). Capsule formation was also significantly inhibited by ZW-DOPA coating in vivo and the differentiation of fibroblasts into myofibroblasts was significantly suppressed. Together, these data suggest that silicone implants coated with ZW-DOPA may prevent capsular contracture after insertion when used in breast surgery.
一种含有儿茶酚和胺基的合成两性离子多巴胺衍生物（ZW-DOPA）最近被证明在海洋表面具有优异的抗污性能。在这里，我们将这些分析扩展到研究 ZW-DOPA 涂层对硅酮植入物的影响。成功地在硅酮植入物上形成 ZW-DOPA 涂层，这是基于硅酮植入物上静态水接触角降低、在 400.2（N 1s）、232.2（S 2s）和 168.0（S 2p） eV 处出现新峰、以及 C 1s 的定量原子组成增加，同时 Si 2p 减少的综合证据来证实的。抗生物膜形成试验表明，ZW-DOPA 涂层可在非致死浓度（0.5 mg mL-1）下阻止硅酮上的生物膜形成。ZW-DOPA 涂层还显著抑制体内胶囊形成，并且成纤维细胞分化为肌成纤维细胞也受到显著抑制。综上所述，这些数据表明，在乳房手术中使用 ZW-DOPA 涂层的硅酮植入物可能会在插入后防止胶囊挛缩。
