一种靶向线粒体的近红外荧光探针，用于在活细胞和糖尿病小鼠模型中成像粘度。
A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model.
机构信息
School of Pharmacy, Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang, 261053, P. R. China.
出版信息
Chem Commun (Camb). 2021 May 4;57(36):4376-4379. doi: 10.1039/d1cc01104a.
PMID:33949482
Abstract
A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect the intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.
摘要
设计了一种具有 700nm 发射波长的线粒体靶向近红外荧光探针 NIR-V，用于高选择性和高灵敏度地监测细胞粘度变化，该探针被用于检测糖尿病小鼠模型中的细胞内粘度和胰腺组织成像。探针 NIR-V 为诊断与粘度相关的疾病提供了一种有效的方法。
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