用于分析线粒体和血液粘度的双转子荧光探针。
A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood.
机构信息
College of Biotechnology and Bioengineering & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
Chem Commun (Camb). 2021 Apr 11;57(28):3508-3511. doi: 10.1039/d1cc00519g. Epub 2021 Mar 10.
PMID:33690772
Abstract
A novel mitochondria-targeting molecular rotator FD was designed to visualize changes in viscosity under hypoxic conditions in vitro and in vivo. Importantly, FD can be used to detect changes in the blood viscosity of liver cancer and liver cirrhosis patients, and also rehabilitation of liver disease.
摘要
设计了一种新型的线粒体靶向分子旋转器 FD，以在体外和体内可视化缺氧条件下的粘度变化。重要的是，FD 可用于检测肝癌和肝硬化患者的血液粘度变化，以及肝病的康复情况。
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