Animal Health Department, Embrapa Southern Region Animal Husbandry, Bagé, Brazil.
Department of Immunology, Adolfo Lutz Institute, São Paulo, Brazil.
Hum Vaccin Immunother. 2021 Sep 2;17(9):2965-2968. doi: 10.1080/21645515.2021.1920272. Epub 2021 May 5.
Although COVID-19 vaccines have recently been approved for emergency use, search for new vaccines are still urgent, since the access of the countries, especially the poorest, to the vaccines, has shown to be slower than the necessary to rapidly control the pandemic. We proposed a novel platform for vaccine using recombinant receptor binding domain (rRBD) from Sars-Cov-2 spike protein and outer membrane vesicles (OMVs). The antigen preparation produced a humoral and cellular immune response. Taken together our findings suggest a good immunostimulatory patter in response to immunization with rRBD plus OMV.
尽管 COVID-19 疫苗最近已获准紧急使用，但新疫苗的研发仍然迫在眉睫，因为各国，尤其是最贫穷国家获得疫苗的速度慢于迅速控制大流行所需的速度。我们提出了一种使用来自 Sars-Cov-2 刺突蛋白和外膜囊泡（OMVs）的重组受体结合域（rRBD）的新型疫苗平台。抗原制备产生了体液和细胞免疫反应。总的来说，我们的研究结果表明，rRBD 加 OMV 免疫可引起良好的免疫刺激模式。
