Department of Medical and Health Sciences, Khawarizmi International College, Abu Dhabi, United Arab Emirates.
Cancer Registry, Tawam Hospital, SEHA, Al Ain, United Arab Emirates.
PLoS One. 2021 May 5;16(5):e0251118. doi: 10.1371/journal.pone.0251118. eCollection 2021.
Data on breast cancer survival and its prognostic factors are lacking in the United Arab Emirates (UAE). Sociodemographic and pathologic factors have been studied widely in western populations but are very limited in this region. This study is the first to report breast cancer survival and investigate prognostic factors associated with its survival in the UAE.
This is a retrospective cohort study involving 988 patients who were diagnosed and histologically confirmed with breast cancer between January 2008 and December 2012 at Tawam hospital, Al Ain, UAE. Patient were followed from the date of initial diagnosis until the date of death from any cause, lost-to-follow up or the end of December 2018. The primary outcome is overall survival (OS). The Kaplan-Meier method was used to estimate the survival curve along with the 2- and 5-year survivals. Different group of patients categorized according to prognostic factors were compared using the log-rank test. Multiple Cox proportional hazards models was used to examine the impact of several prognostic factors on the overall survival.
The median study follow-up was 35 months. Of the 988 patients, 62 had died during their follow-up, 56 were lost to follow-up and 870 were still alive at the end of the study. The average age of patients was 48 years. The majority of patients presented to the hospital with grade II or III, 24% with at least stage 3 and 9.2% had metastasis. The 2-year and 5-year survivals were estimated to 97% and 89% respectively. Results of the multiple Cox proportional hazard model show that tumor grade, and stage of cancer at presentation are jointly significantly associated with survival.
The 2- and 5-year survival are within the norms compared to other countries. Significant clinical and pathological prognostic factors associated with survival were tumor grade, and the stage of cancer at presentation.
在阿拉伯联合酋长国（阿联酋），缺乏有关乳腺癌生存及其预后因素的数据。在西方人群中，已经广泛研究了社会人口学和病理学因素，但在该地区非常有限。这项研究首次报告了阿联酋的乳腺癌生存情况，并探讨了与生存相关的预后因素。
这是一项回顾性队列研究，涉及 988 名 2008 年 1 月至 2012 年 12 月期间在阿联酋艾因的 Tawam 医院被诊断和组织学证实患有乳腺癌的患者。患者从初始诊断日期开始随访，直至任何原因死亡、失访或 2018 年 12 月结束。主要结局是总生存（OS）。使用 Kaplan-Meier 方法估计生存曲线以及 2 年和 5 年生存率。根据预后因素对不同组别的患者进行分类，并使用对数秩检验进行比较。使用多 Cox 比例风险模型检查几个预后因素对总体生存的影响。
中位研究随访时间为 35 个月。在 988 名患者中，62 人在随访期间死亡，56 人失访，870 人在研究结束时仍存活。患者的平均年龄为 48 岁。大多数患者因 II 级或 III 级就诊，24%至少为 3 期，9.2%有转移。2 年和 5 年生存率估计分别为 97%和 89%。多 Cox 比例风险模型的结果表明，肿瘤分级和就诊时癌症分期与生存显著相关。
与其他国家相比，2 年和 5 年生存率在正常范围内。与生存相关的显著临床和病理预后因素是肿瘤分级和就诊时癌症分期。
