Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaounde, Cameroon.
Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon.
Nat Prod Res. 2022 Oct;36(19):5039-5047. doi: 10.1080/14786419.2021.1920017. Epub 2021 May 6.
Bioassay-guided fractionation of the CHCl-MeOH (1:1) leaves extract of , yielded two new vilasinin-type limonoids named gilgianin A () and gilgianin B (), one new phenyl alkene derivative designated as gilgialkene A (), along with six known compounds: rubescin H (), TS3 (), trichirubine A (), sitosteryl-6'--undecanoate--D-glucoside (), scopoletin (), and octadecane-2-one (). Their structures were elucidated based on spectroscopic analysis and comparison with literature data. Compounds and exhibited the highest antiplasmodial activity with IC values of 1.14 and 1.32 μM respectively. Moreover, compound was very cytotoxic with CC value of 0.88 µM, compared to compound , which was not cytotoxic (CC > 10 µg/mL). Compounds IC = 9.84 µM), (IC = 11.04 µM) and (IC = 10.71 µM) presented good antiplasmodial activity while also exhibiting significant cytotoxicity, with CC values ranging from of 14.45 to 29.7 µM.[Formula: see text].
基于生物测定导向的 CHCl-MeOH（1:1）叶提取物分离，得到了两种新的维拉西宁型柠檬苦素，分别命名为吉利亚宁 A（）和吉利亚宁 B（），一种新的苯丙烯衍生物命名为吉利亚烯 A（），以及六种已知化合物：红穗槐素 H（）、TS3（）、三刺槐素 A（）、豆甾醇-6'--十一烷酸--D-葡萄糖苷（）、东莨菪内酯（）和十八烷-2-酮（）。它们的结构是基于光谱分析和与文献数据的比较来阐明的。化合物和表现出最高的抗疟原虫活性，IC 值分别为 1.14 和 1.32 μM。此外，化合物的细胞毒性非常强，CC 值为 0.88 μM，而化合物则没有细胞毒性（CC > 10 μM）。化合物（IC = 9.84 μM）、（IC = 11.04 μM）和（IC = 10.71 μM）表现出良好的抗疟原虫活性，同时也表现出显著的细胞毒性，CC 值范围为 14.45 至 29.7 μM。
