N-酰基三嗪二酮；一种由三嗪酮型缩合试剂合成的新型酰化试剂。
N-Acyltriazinedione; a Novel Acylating Reagent Synthesized from a Triazinone-Type Condensing Reagent.
作者信息
Yamada Kohei, Lee Jeongsu, Kota Mika, Karuo Yukiko, Kitamura Masanori, Kunishima Munetaka
机构信息
Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University.
出版信息
Chem Pharm Bull (Tokyo). 2021;69(5):498-502. doi: 10.1248/cpb.c20-00952.
PMID:33952859
Abstract
In this paper, we report the synthesis of N-acyltriazinedione via the unexpected O-N acyl rearrangement of acyloxytriazinone and its utility as an acylating reagent. N-Acyltriazinedione can be isolated by silica gel column chromatography and reacts with amines in the absence of any base to give the corresponding amides in good yields.
摘要
在本文中，我们报道了通过酰氧基三嗪酮意外的O-N酰基重排反应合成N-酰基三嗪二酮及其作为酰化试剂的用途。N-酰基三嗪二酮可通过硅胶柱色谱法分离，并在无任何碱的情况下与胺反应，以良好的产率得到相应的酰胺。
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