Aragón Institute of Engineering Research (i3A), University of Zaragoza, Mariano Esquillor s/n, Zaragoza, 50018, Spain.
Centro de Investigación Biomédica en Red en Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain.
Sci Rep. 2021 May 5;11(1):9639. doi: 10.1038/s41598-021-89145-z.
The purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stretched from the accommodated state to the non-accommodated state. Several key characteristics of the lens were studied: the stiffness gradient of the lens material, the distribution of the capsule thickness, the mechanical properties of the capsule and the material comprising the lens, nucleus and cortex, and the influence of two different age-related lens geometries (17 and 29 y/o subjects). To determine the effects on the changes in lens shape during accommodation, changes in the anterior and posterior radius, the lens and nucleus thicknesses and the equatorial lens diameter were analysed. The results suggest that multiple factors exert statistically significant influences on how the lens changes its shape, but two factors predominate over the rest: the stiffness ratio between the nucleus and cortex and the stiffness of the capsule, specifically the posterior surface.
本研究旨在探讨晶状体的力学性能和几何形状如何影响调节过程中晶状体形状的变化。为此，通过有限元分析模拟了离体晶状体的拉伸试验。在这些试验中，晶状体从调节状态拉伸至非调节状态。研究了晶状体的几个关键特征：晶状体材料的刚度梯度、囊膜厚度的分布、囊膜和包含晶状体核和皮质的材料的力学性能，以及两种不同年龄相关的晶状体几何形状（17 岁和 29 岁受试者）的影响。为了确定这些因素对调节过程中晶状体形状变化的影响，分析了前、后表面曲率半径、晶状体和核厚度以及赤道晶状体直径的变化。结果表明，有多个因素对晶状体形状的变化有统计学显著影响，但有两个因素比其他因素更为重要：晶状体核和皮质之间的刚度比以及囊膜的刚度，特别是后表面的刚度。
