阴茎阴囊外佩吉特病的根治性放疗：1例长期随访病例报告
Definitive Radiotherapy for Penoscrotal Extramammary Paget's Disease: A Case Report with Long-Term Follow-Up.
作者信息
Suzuki Gen, Machida Kazutaka, Asato Akito, Seri Sho, Ikemoto Chika, Yamazaki Hideya, Yamada Kei, Katsumori Tetsuya
机构信息
Department of Radiology, Saiseikai Shiga Hospital, Ritto, Shiga, Japan.
Department of Radiology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
出版信息
Clin Med Insights Case Rep. 2021 Apr 10;14:11795476211009251. doi: 10.1177/11795476211009251. eCollection 2021.
Penoscrotal extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma in older male patients, and no effective nonsurgical treatment strategies are currently available. The aim of this study was to report the usefulness of external radiotherapy (RT) for penoscrotal EMPD in an inoperable elderly patient. This report presents the treatment of an 89-year-old man with widespread penoscrotal EMPD. A multidisciplinary treatment team decided on radical RT. The patient received a radiation dose of 61.8 Gy in 30 fractions through electron and photon beams. His treatment tolerance was good, and no severe toxicity had been observed up the last follow-up. At 6.5 years after the RT, the patient showed no evidence of recurrence. Definitive RT resulted in excellent disease control and minimal toxicity; thus, it could be a promising nonsurgical therapeutic option for penoscrotal EMPD, even in extremely elderly individuals.
阴茎阴囊部乳腺外佩吉特病（EMPD）是一种发生于老年男性患者的罕见上皮内腺癌，目前尚无有效的非手术治疗策略。本研究的目的是报告外照射放疗（RT）对一名无法手术的老年阴茎阴囊部EMPD患者的有效性。本报告介绍了一名89岁广泛阴茎阴囊部EMPD男性患者的治疗情况。一个多学科治疗团队决定进行根治性放疗。患者通过电子束和光子束分30次接受了61.8 Gy的辐射剂量。他的治疗耐受性良好，直至最后一次随访均未观察到严重毒性反应。放疗后6.5年，患者无复发迹象。根治性放疗实现了良好的疾病控制且毒性极小；因此，即使对于极高龄个体，它也可能是阴茎阴囊部EMPD一种有前景的非手术治疗选择。
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