Interference of with in the treatment of infected burns in Wistar rats.

OBJECTIVES

Burns are the most common type of trauma with a high mortality rate worldwide. The use of modern and natural medicines, especially probiotic products, has been recently considered for cutaneous wound healing. The present study was designed to investigate the effect of on wound healing caused by .

MATERIALS AND METHODS

In this study, the anti-adhesion activity of was examined by the glass slide method, and inhibitory substances in the cell-free supernatant (CFS) were quantified by high-performance liquid chromatography (HPLC). Following the induction of second-degree wounds, multidrug-resistant (MDR) was injected subcutaneously and directly on the burn. The animals were divided into four groups. The supernatant of was sprayed for treatment every day and wound healing was examined.

RESULTS

Based on our findings, the supernatant of showed considerable anti-adhesion effects on . HPLC analysis indicated that the inhibitory effect of this supernatant can be due to four main organic acids including lactic acid, acetic acid, citric acid, and succinic acid. The effect of treatment on fibroblastic cells showed that the treated group by supernatant of had more fibroblastic cells compared with the non-treated group. Moreover, this supernatant increased the rate of fibroblastic cells, re-epithelialization in the wound area, and the largest thickness of the epidermis and dermis layers.

CONCLUSION

The present findings showed that supernatant significantly reduced inflammation and could be used to treat infection in second-degree burns.