Department of Microbiology, Faculty of Biology, University of Bucharest, 030018 București, Romania.
Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.
Int J Mol Sci. 2024 May 24;25(11):5723. doi: 10.3390/ijms25115723.
Wound infections caused by opportunistic bacteria promote persistent infection and represent the main cause of delayed healing. Probiotics are acknowledged for their beneficial effects on the human body and could be utilized in the management of various diseases. They also possess the capacity to accelerate wound healing, due to their remarkable anti-pathogenic, antibiofilm, and immunomodulatory effects. Oral and topical probiotic formulations have shown promising openings in the field of dermatology, and there are various in vitro and in vivo models focusing on their healing mechanisms. Wound dressings embedded with prebiotics and probiotics are now prime candidates for designing wound healing therapeutic approaches to combat infections and to promote the healing process. The aim of this review is to conduct an extensive scientific literature review regarding the efficacy of oral and topical probiotics in wound management, as well as the potential of wound dressing embedding pre- and probiotics in stimulating the wound healing process.
机会性细菌引起的伤口感染会导致持续性感染，这也是延迟愈合的主要原因。益生菌对人体有有益的影响，可用于治疗各种疾病。由于其具有显著的抗病原、抗生物膜和免疫调节作用，益生菌也具有加速伤口愈合的能力。口腔和局部益生菌制剂在皮肤病学领域展现出了广阔的应用前景，目前有各种体外和体内模型专注于研究其愈合机制。目前，含有益生菌和益生元的伤口敷料是设计伤口愈合治疗方法以对抗感染和促进愈合过程的首选。本综述的目的是对口服和局部益生菌在伤口管理中的功效进行广泛的科学文献回顾，以及伤口敷料中嵌入前体和益生菌在刺激伤口愈合过程中的潜力。
