Velichko M G, Ostrovskiĭ Iu M, Trebukhina R V
Vopr Med Khim. 1978 Mar-Apr;24(2):220-4.
Correlation between pyruvate and lactate contents as well as between enzymes participating in turnover of the substrates (pyruvate- and lactate dehydrogenases, alanine aminotransferase, pyruvate kinase) were studied in rat liver tissue simultaneously with tumor growth and intensive thiaminotherapy. Thiamine, administered into rats carrying carcinosarcoma Woker-256 at a daily dose 12.5 mg/kg body weight, exhibited the normalizing effect on activity of enzymes studied, on quantitative content of LDH isoenzymes and on content of lactate in blood and of pyruvate in liver tissue. Possible effect of thiamine on pyruvate metabolism in tumoral impairment is discussed.
在大鼠肝脏组织中，同时研究了丙酮酸和乳酸含量之间以及参与底物代谢的酶（丙酮酸脱氢酶、乳酸脱氢酶、丙氨酸转氨酶、丙酮酸激酶）之间的相关性，实验过程伴随肿瘤生长和强化硫胺素治疗。给携带沃克-256癌肉瘤的大鼠每日按12.5mg/kg体重的剂量注射硫胺素，结果显示该药物对所研究的酶活性、LDH同工酶的定量含量以及血液中乳酸和肝脏组织中丙酮酸的含量均有正常化作用。文中还讨论了硫胺素对肿瘤损伤中丙酮酸代谢的可能影响。
