Department of Dermatology, Ghent University Hospital, BE-9000 Gent, Belgium. E-mail:
Acta Derm Venereol. 2021 Jun 28;101(6):adv00481. doi: 10.2340/00015555-3823.
Identifying which factors contribute to vitiligo severity and determining their individual weight are important in the management of vitiligo. The aim of this study is to investigate the predictive variables concerning vitiligo severity as perceived by the patients. Based on a questionnaire, several factors that may contribute to the Patient Global Assessment (PtGA) of severity were investigated within a Belgian vitiligo population (n = 291). In addition, possible factors influencing vitiligo severity were scored and ranked. The strongest correlations with the PtGA of severity were found for impact, Dermatology Life Quality Index and disease extent. Based on multivariable regression analyses, 64.7% of PtGA of severity could be predicted by subjective and objective variables, while 32% could be explained by objective clinical features only. Patients considered lesion location, extent and disease activity as the most important contributing factors to severity. Vitiligo severity is determined by objective clinical features, but also, for a significant part, by the perceived impact of the disease.
确定哪些因素会导致白癜风的严重程度，并确定它们各自的权重，这对于白癜风的治疗管理非常重要。本研究旨在探讨患者感知的与白癜风严重程度相关的预测变量。基于问卷调查，对 291 名比利时白癜风患者的多项可能导致严重程度的个体因素进行了研究。此外，还对可能影响白癜风严重程度的因素进行了评分和排序。与严重程度的 PtGA 相关性最强的因素为影响、皮肤病生活质量指数和疾病范围。基于多变量回归分析，64.7%的 PtGA 严重程度可以通过主观和客观变量来预测，而 32%的 PtGA 严重程度可以仅通过客观临床特征来解释。患者认为病变位置、范围和疾病活动是导致严重程度的最重要因素。白癜风的严重程度是由客观的临床特征决定的，但在很大程度上也受到疾病感知影响的决定。
