减肥手术对中度至重度银屑病的影响：一项全国性回顾性登记研究。
Impact of Bariatric Surgery on Moderate to Severe Psoriasis: A Retrospective Nationwide Registry Study.
作者信息
Laskowski Marta, Schiöler Linus, Ottosson Johan, Schmitt-Egenolf Marcus, Wennberg Ann-Marie, Olbers Torsten, Torén Kjell, Gustafsson Helena
机构信息
Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden. E-mail:
出版信息
Acta Derm Venereol. 2021 Jun 30;101(6):adv00487. doi: 10.2340/00015555-3825.
Studies of the effects of bariatric surgery on psoriasis are few, with conflicting results. By linking the Swedish National Register for Systemic Treatment of Psoriasis (PsoReg) with the Scandinavian Obesity Surgery Registry (SOReg), individuals with psoriasis who had undergone bariatric surgery in Sweden during 2008 to 2018 were identified, and matched with data for patients with psoriasis in PsoReg. Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) were compared between the groups. Altogether, 50 operated individuals (median body mass index (BMI) 38.7 kg/m2]) and 91 non-operated individuals (median BMI 33.0 kg/m2) were included. Control of disease at baseline was good in both groups. Linear mixed models showed no significant difference in psoriasis disease burden, measured as changes in mean PASI (ΔPASI) (-1.2, p = 0.43) and DLQI (ΔDLQI) (-2.2, p = 0.34). In summary, this study demonstrated no significant effect of bariatric surgery on psoriasis disease burden in patients with relatively well-controlled moderate to severe psoriasis.
关于减肥手术对银屑病影响的研究较少，且结果相互矛盾。通过将瑞典全国银屑病系统治疗登记册（PsoReg）与斯堪的纳维亚肥胖手术登记册（SOReg）相链接，确定了2008年至2018年期间在瑞典接受减肥手术的银屑病患者，并与PsoReg中银屑病患者的数据进行匹配。比较了两组之间的银屑病面积和严重程度指数（PASI）以及皮肤病生活质量指数（DLQI）。总共纳入了50名接受手术的个体（中位体重指数（BMI）为38.7kg/m²）和91名未接受手术的个体（中位BMI为33.0kg/m²）。两组在基线时疾病控制情况均良好。线性混合模型显示，以平均PASI变化（ΔPASI）（-1.2，p = 0.43）和DLQI变化（ΔDLQI）（-2.2，p = 0.34）衡量的银屑病疾病负担没有显著差异。总之，本研究表明，减肥手术对中度至重度银屑病控制相对良好的患者的银屑病疾病负担没有显著影响。
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