Zibandeh Noushin, Genc Deniz, Ozgen Zuleyha, Duran Yazgul, Goker Kamil, Baris Safa, Ergun Tulin, Akkoc Tunc
Division of Pediatric Allergy & Immunology, Marmara University, Istanbul, Turkey.
Koc University Research Center for Translational Medicine, Koc University, Istanbul, Turkey.
Immunotherapy. 2021 Jul;13(10):825-840. doi: 10.2217/imt-2020-0257. Epub 2021 May 6.
Atopic dermatitis (AD) is an inflammatory cutaneous disorder. The advancements in the understanding of AD immunological pathogenesis have caused the development of therapies that suppress the dysregulated immune response. We aimed to evaluate the immunomodulatory effect of dental stem cells (dental follicle-mesenchymal stem cells [DF-MSCs]) on AD patients. We investigated the immunoregulatory potential of DF-MSCs on T cell response in AD and compared them with psoriasis and healthy individuals and the underlying mechanisms. DF-MSCs significantly reduced Fas, FasL and TNFR II frequency in T cells, increased naive T cell population while reducing memory T cell, decreased inflammatory cytokine levels and promoted Tregs frequency in the AD population. These results imply that DF-MSCs are modulating inflammation through decreasing T cell apoptosis, inducing Treg expansion and stabilizing cytokine levels.
特应性皮炎（AD）是一种炎症性皮肤病。对AD免疫发病机制认识的进展促使了抑制失调免疫反应的疗法的发展。我们旨在评估牙干细胞（牙囊间充质干细胞[DF-MSCs]）对AD患者的免疫调节作用。我们研究了DF-MSCs对AD中T细胞反应的免疫调节潜力，并将其与银屑病患者和健康个体进行比较，以及探讨其潜在机制。DF-MSCs显著降低了AD人群T细胞中Fas、FasL和TNFR II的频率，增加了初始T细胞群体，同时减少了记忆T细胞，降低了炎症细胞因子水平，并促进了调节性T细胞（Tregs）的频率。这些结果表明，DF-MSCs通过减少T细胞凋亡、诱导Tregs扩增和稳定细胞因子水平来调节炎症。
