Palagi B, Picozzi R, Casazza F, Possa M, Magri G, Zoccarato O, Graziano E, Ferrari F, Morpurgo M
Division of Nuclear Medicine, Hospital of Saronno, Varese, Italy.
Br Heart J. 1988 Jun;59(6):692-5. doi: 10.1136/hrt.59.6.692.
The systolic and diastolic function of both ventricles was assessed by radionuclide angiography in 21 patients with Friedreich's ataxia and hypertrophic cardiomyopathy. The indices of systolic function of the two ventricles and those of diastolic function of the right ventricle were generally normal. But in patients with Friedreich's ataxia the time to peak filling rate divided by the diastolic time of the left ventricle was significantly larger than normal. The increase correlated with the heart rate (r = 0.79) and this suggests an alteration in the timing of ventricle filling that is more evident at high heart rates. Movement of the left ventricle was little impaired; however, in 48% of the patients with Friedreich's ataxia the right ventricle showed evidence of hypokinetic segments. Because there is a tendency for congestive heart failure to develop in patients with Friedreich's ataxia, this hypokinesis of the right ventricle should be monitored at follow up.
通过放射性核素血管造影术对21例患有弗里德赖希共济失调和肥厚型心肌病的患者的双心室收缩和舒张功能进行了评估。两个心室的收缩功能指标以及右心室的舒张功能指标总体上是正常的。但是在患有弗里德赖希共济失调的患者中，左心室的峰值充盈率时间除以舒张时间明显高于正常水平。这种增加与心率相关（r = 0.79），这表明心室充盈时间发生了改变，在高心率时更为明显。左心室的运动几乎没有受损；然而，在48%的患有弗里德赖希共济失调的患者中，右心室显示出运动减弱节段的迹象。由于患有弗里德赖希共济失调的患者有发生充血性心力衰竭的倾向，因此在随访中应监测右心室的这种运动减弱情况。
